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{{STRUCTURE_4mak|  PDB=4mak  |  SCENE=  }}
==Crystal structure of a putative ssRNA endonuclease Cas2, CRISPR adaptation protein from E.coli==
===Crystal structure of a putative ssRNA endonuclease Cas2, CRISPR adaptation protein from E.coli===
<StructureSection load='4mak' size='340' side='right' caption='[[4mak]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4mak]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_str._k-12_substr._mg1655 Escherichia coli str. k-12 substr. mg1655]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MAK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ygbF, cas2, b2754, JW5438 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=511145 Escherichia coli str. K-12 substr. MG1655])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mak OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mak RCSB], [http://www.ebi.ac.uk/pdbsum/4mak PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CAS2_ECOLI CAS2_ECOLI]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).<ref>PMID:21255106</ref>   
[[http://www.uniprot.org/uniprot/CAS2_ECOLI CAS2_ECOLI]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).<ref>PMID:21255106</ref>   


==About this Structure==
==See Also==
[[4mak]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_str._k-12_substr._mg1655 Escherichia coli str. k-12 substr. mg1655]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MAK OCA].
*[[Endonuclease|Endonuclease]]
 
== References ==
==Reference==
<references/>
<references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli str. k-12 substr. mg1655]]
[[Category: Escherichia coli str. k-12 substr. mg1655]]
[[Category: Brown, G.]]
[[Category: Brown, G]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak, A]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Structural genomic]]
[[Category: Nocek, B.]]
[[Category: Nocek, B]]
[[Category: Skarina, T.]]
[[Category: Skarina, T]]
[[Category: Yakunin, A.]]
[[Category: Yakunin, A]]
[[Category: Cas2]]
[[Category: Cas2]]
[[Category: Crispr]]
[[Category: Crispr]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Mcsg]]
[[Category: Mcsg]]
[[Category: Midwest center for structural genomic]]
[[Category: Psi-biology]]
[[Category: Psi-biology]]
[[Category: Structural genomic]]

Revision as of 19:04, 25 December 2014

Crystal structure of a putative ssRNA endonuclease Cas2, CRISPR adaptation protein from E.coliCrystal structure of a putative ssRNA endonuclease Cas2, CRISPR adaptation protein from E.coli

Structural highlights

4mak is a 2 chain structure with sequence from Escherichia coli str. k-12 substr. mg1655. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:ygbF, cas2, b2754, JW5438 (Escherichia coli str. K-12 substr. MG1655)
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[CAS2_ECOLI] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).[1]

See Also

References

  1. ↑ Perez-Rodriguez R, Haitjema C, Huang Q, Nam KH, Bernardis S, Ke A, DeLisa MP. Envelope stress is a trigger of CRISPR RNA-mediated DNA silencing in Escherichia coli. Mol Microbiol. 2011 Feb;79(3):584-99. doi: 10.1111/j.1365-2958.2010.07482.x. Epub, 2010 Dec 13. PMID:21255106 doi:10.1111/j.1365-2958.2010.07482.x

4mak, resolution 1.10Å

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