1nkl: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1nkl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NKL FirstGlance]. <br> | <table><tr><td colspan='2'>[[1nkl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NKL FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nkl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nkl RCSB], [http://www.ebi.ac.uk/pdbsum/1nkl PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nkl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nkl RCSB], [http://www.ebi.ac.uk/pdbsum/1nkl PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/NKL_PIG NKL_PIG]] May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
[[Category: Liepinsh, E | [[Category: Liepinsh, E]] | ||
[[Category: Otting, G | [[Category: Otting, G]] | ||
[[Category: Antibacterial peptide]] | [[Category: Antibacterial peptide]] | ||
[[Category: Saposin fold]] | [[Category: Saposin fold]] | ||
[[Category: Tumourolytic peptide]] | [[Category: Tumourolytic peptide]] | ||
Revision as of 18:58, 25 December 2014
NK-LYSIN FROM PIG, NMR, 20 STRUCTURESNK-LYSIN FROM PIG, NMR, 20 STRUCTURES
Structural highlights
Function[NKL_PIG] May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedNK-lysin is the first representative of a family of sequence related proteins--saposins, surfactant-associated protein B, pore forming amoeba proteins, and domains of acid sphingomyelinase, acyloxyacylhydrolase and plant aspartic proteinases--for which a structure has been determined. Saposin fold revealed by the NMR structure of NK-lysin.,Liepinsh E, Andersson M, Ruysschaert JM, Otting G Nat Struct Biol. 1997 Oct;4(10):793-5. PMID:9334742[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References |
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