2yf5: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yf5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yf5 RCSB], [http://www.ebi.ac.uk/pdbsum/2yf5 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yf5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yf5 RCSB], [http://www.ebi.ac.uk/pdbsum/2yf5 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/B2MG_CHICK B2MG_CHICK]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
==See Also== | |||
*[[Beta-2 microglobulin|Beta-2 microglobulin]] | |||
*[[Major histocompatibility complex|Major histocompatibility complex]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Gallus gallus]] | [[Category: Gallus gallus]] | ||
[[Category: Chappell, P | [[Category: Chappell, P]] | ||
[[Category: Harrison, M C | [[Category: Harrison, M C]] | ||
[[Category: Kaufman, J F | [[Category: Kaufman, J F]] | ||
[[Category: Lea, S M | [[Category: Lea, S M]] | ||
[[Category: Mears, L E | [[Category: Mears, L E]] | ||
[[Category: Roversi, P | [[Category: Roversi, P]] | ||
[[Category: Immune response]] | [[Category: Immune response]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Immunoglobulin domain]] | [[Category: Immunoglobulin domain]] | ||
[[Category: Mhc i]] | [[Category: Mhc i]] | ||
Revision as of 18:57, 25 December 2014
COMPLEX OF A B21 CHICKEN MHC CLASS I MOLECULE AND A 10MER CHICKEN PEPTIDECOMPLEX OF A B21 CHICKEN MHC CLASS I MOLECULE AND A 10MER CHICKEN PEPTIDE
Structural highlights
Function[B2MG_CHICK] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Publication Abstract from PubMedLittle is known about the structure of major histocompatibility complex (MHC) molecules outside of mammals. Only one class I molecule in the chicken MHC is highly expressed, leading to strong genetic associations with infectious pathogens. Here, we report two structures of the MHC class I molecule BF2*2101 from the B21 haplotype, which is known to confer resistance to Marek's disease caused by an oncogenic herpesvirus. The binding groove has an unusually large central cavity, which confers substantial conformational flexibility to the crucial residue Arg9, allowing remodeling of key peptide-binding sites. The coupled variation of anchor residues from the peptide, utilizing a charge-transfer system unprecedented in MHC molecules, allows peptides with conspicuously different sequences to be bound. This promiscuous binding extends our understanding of ways in which MHC class I molecules can present peptides to the immune system and might explain the resistance of the B21 haplotype to Marek's disease. Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding.,Koch M, Camp S, Collen T, Avila D, Salomonsen J, Wallny HJ, van Hateren A, Hunt L, Jacob JP, Johnston F, Marston DA, Shaw I, Dunbar PR, Cerundolo V, Jones EY, Kaufman J Immunity. 2007 Dec;27(6):885-99. PMID:18083574[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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