4ael: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AEL FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AEL FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HN:2-(2-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE'>4HN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HN:2-(2-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE'>4HN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2y5v|2y5v]], [[1lrb|1lrb]], [[2wey|2wey]], [[2y5x|2y5x]], [[2y5u|2y5u]], [[2y0j|2y0j]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2y5v|2y5v]], [[1lrb|1lrb]], [[2wey|2wey]], [[2y5x|2y5x]], [[2y5u|2y5u]], [[2y0j|2y0j]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ael FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ael OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ael RCSB], [http://www.ebi.ac.uk/pdbsum/4ael PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ael FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ael OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ael RCSB], [http://www.ebi.ac.uk/pdbsum/4ael PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bauer, M | [[Category: Bauer, M]] | ||
[[Category: Bauer, U | [[Category: Bauer, U]] | ||
[[Category: Carlsson, E Toppner | [[Category: Carlsson, E Toppner]] | ||
[[Category: Enroth, C | [[Category: Enroth, C]] | ||
[[Category: Giordanetto, F | [[Category: Giordanetto, F]] | ||
[[Category: Hartleib-Geschwindner, J | [[Category: Hartleib-Geschwindner, J]] | ||
[[Category: Johansson, K E | [[Category: Johansson, K E]] | ||
[[Category: Knecht, W | [[Category: Knecht, W]] | ||
[[Category: Omahony, G | [[Category: Omahony, G]] | ||
[[Category: Sjogren, T | [[Category: Sjogren, T]] | ||
[[Category: Enzyme inhibitor]] | [[Category: Enzyme inhibitor]] | ||
[[Category: Hit-to-lead]] | [[Category: Hit-to-lead]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Naphtyridine]] | [[Category: Naphtyridine]] | ||