2duv: Difference between revisions

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Revision as of 17:31, 20 March 2008

File:2duv.jpg

, resolution 2.2Å

Ligands:

Activity:

Cyclin-dependent kinase, with EC number 2.7.11.22

Coordinates:

save as pdb, mmCIF, xml

Structure of CDK2 with a 3-hydroxychromones

OverviewOverview

A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.

About this StructureAbout this Structure

2DUV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:17178224

Page seeded by OCA on Thu Mar 20 16:31:54 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2duv.jpg|left|200px]]<br /><applet load="2duv" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2duv.jpg|left|200px]]
-caption="2duv, resolution 2.2&Aring;" />
-'''Structure of CDK2 with a 3-hydroxychromones'''<br />
+ {{Structure
+|PDB= 2duv |SIZE=350|CAPTION= <scene name='initialview01'>2duv</scene>, resolution 2.2&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=371:2-(3,4-DIHYDROXYPHENYL)-8-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-3-HYDROXY-6-METHYL-4H-CHROMEN-4-ONE'>371</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22]
+|GENE=
+}}
+'''Structure of CDK2 with a 3-hydroxychromones'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-DUV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=371:'>371</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DUV OCA].
+DUV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DUV OCA].
 ==Reference==
--Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17178224 17178224]
+-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17178224 17178224]
 [[Category: Cyclin-dependent kinase]]
 [[Category: Homo sapiens]]
@@ Line 24: / Line 33: @@
 [[Category: serine/threonine-protein kinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:02:56 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:31:54 2008''