4npk: Difference between revisions

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-{{STRUCTURE_4npk|  PDB=4npk  |  SCENE=  }}
+==Extended-Synaptotagmin 2, C2A- and C2B-domains, calcium bound==
-===Extended-Synaptotagmin 2, C2A- and C2B-domains, calcium bound===
+<StructureSection load='4npk' size='340' side='right' caption='[[4npk]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
-{{ABSTRACT_PUBMED_24373768}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4npk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NPK FirstGlance]. <br>
-==Function==
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4npj|4npj]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ESYT2, extended-synaptotagmin 2, FAM62B, KIAA1228 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4npk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4npk RCSB], [http://www.ebi.ac.uk/pdbsum/4npk PDBsum]</span></td></tr>
+</table>
+== Function ==
 [[http://www.uniprot.org/uniprot/ESYT2_HUMAN ESYT2_HUMAN]] May play a role as calcium-regulated intrinsic membrane protein.<ref>PMID:17360437</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Contacts between the endoplasmic reticulum and the plasma membrane involve extended synaptotagmins (E-Syts) in mammals or tricalbins in yeast, proteins with multiple C2 domains. One of the tandem C2 domains of E-Syt2 is predicted to bind Ca2+, but no Ca2+-dependent function has been attributed to this protein. We have determined the crystal structures of the tandem C2 domains of E-Syt2 in the absence and presence of Ca2+ and analyzed their Ca2+-binding properties by nuclear magnetic resonance spectroscopy. Our data reveal an unexpected V-shaped structure with a rigid orientation between the two C2 domains that is not substantially altered by Ca2+. The E-Syt2 C2A domain binds up to four Ca2+ ions, whereas the C2B domain does not bind Ca2+. These results suggest that E-Syt2 performs an as yet unidentified Ca2+-dependent function through its C2A domain and uncover fundamental differences between the properties of the tandem C2 domains of E-Syts and synaptotagmins.
-==About this Structure==
+Structure and Ca-Binding Properties of the Tandem C Domains of E-Syt2.,Xu J, Bacaj T, Zhou A, Tomchick DR, Sudhof TC, Rizo J Structure. 2013 Dec 24. pii: S0969-2126(13)00461-9. doi:, 10.1016/j.str.2013.11.011. PMID:24373768<ref>PMID:24373768</ref>
-[[4npk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPK OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:024373768</ref><references group="xtra"/><references/>
+</div>
-[[Category: Rizo, J.]]
+== References ==
-[[Category: Tomchick, D R.]]
+<references/>
-[[Category: Xu, J.]]
+__TOC__
+</StructureSection>
+[[Category: Human]]
+[[Category: Rizo, J]]
+[[Category: Tomchick, D R]]
+[[Category: Xu, J]]
 [[Category: C2 domain]]
 [[Category: Calcium/phospholipid binding protein]]