4mh0: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4mh0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MH0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4mh0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MH0 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HR4:(2S,4AR,6R,7R,7AS)-6-{6-AMINO-8-[(4-FLUOROBENZYL)SULFANYL]-9H-PURIN-9-YL}-2-SULFANYLTETRAHYDRO-4H-FURO[3,2-D][1,3,2]DIOXAPHOSPHININ-7-OL+2-OXIDE'>HR4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HR4:(2S,4AR,6R,7R,7AS)-6-{6-AMINO-8-[(4-FLUOROBENZYL)SULFANYL]-9H-PURIN-9-YL}-2-SULFANYLTETRAHYDRO-4H-FURO[3,2-D][1,3,2]DIOXAPHOSPHININ-7-OL+2-OXIDE'>HR4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2byv|2byv]], [[3cf6|3cf6]], [[4mgi|4mgi]], [[4mgk|4mgk]], [[4mgy|4mgy]], [[4mgz|4mgz]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2byv|2byv]], [[3cf6|3cf6]], [[4mgi|4mgi]], [[4mgk|4mgk]], [[4mgy|4mgy]], [[4mgz|4mgz]]</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mh0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mh0 RCSB], [http://www.ebi.ac.uk/pdbsum/4mh0 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mh0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mh0 RCSB], [http://www.ebi.ac.uk/pdbsum/4mh0 PDBsum]</span></td></tr>
<table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/RPGF4_MOUSE RPGF4_MOUSE]] Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.<ref>PMID:11056535</ref>  [[http://www.uniprot.org/uniprot/RAP1B_HUMAN RAP1B_HUMAN]] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.<ref>PMID:20332120</ref> <ref>PMID:18660803</ref> 
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Rehmann, H.]]
[[Category: Rehmann, H]]
[[Category: Guanine nucleotide exchange factor]]
[[Category: Guanine nucleotide exchange factor]]
[[Category: Nucleotide binding]]
[[Category: Nucleotide binding]]
[[Category: Signaling protein-gtp-binding protein complex]]
[[Category: Signaling protein-gtp-binding protein complex]]

Revision as of 16:12, 25 December 2014

Selective activation of Epac1 and Epac2Selective activation of Epac1 and Epac2

Structural highlights

4mh0 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[RPGF4_MOUSE] Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.[1] [RAP1B_HUMAN] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.[2] [3]

References

  1. ↑ Ozaki N, Shibasaki T, Kashima Y, Miki T, Takahashi K, Ueno H, Sunaga Y, Yano H, Matsuura Y, Iwanaga T, Takai Y, Seino S. cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000 Nov;2(11):805-11. PMID:11056535 doi:http://dx.doi.org/10.1038/35041046
  2. ↑ Lampugnani MG, Orsenigo F, Rudini N, Maddaluno L, Boulday G, Chapon F, Dejana E. CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci. 2010 Apr 1;123(Pt 7):1073-80. doi: 10.1242/jcs.059329. PMID:20332120 doi:10.1242/jcs.059329
  3. ↑ Rehmann H, Arias-Palomo E, Hadders MA, Schwede F, Llorca O, Bos JL. Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. Nature. 2008 Sep 4;455(7209):124-7. Epub 2008 Jul 27. PMID:18660803 doi:http://dx.doi.org/10.1038/nature07187

4mh0, resolution 2.40Å

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