2cu7: Difference between revisions

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Revision as of 17:19, 20 March 2008

File:2cu7.gif

Gene:

KIAA1915 (Homo sapiens)

Coordinates:

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Solution structure of the SANT domain of human KIAA1915 protein

OverviewOverview

SWIRM is a conserved domain found in several chromatin-associated proteins. Based on their sequences, the SWIRM family members can be classified into three subfamilies, which are represented by Swi3, LSD1, and Ada2. Here we report the SWIRM structure of human MYb-like, Swirm and Mpn domain-containing protein-1 (MYSM1). The MYSM1 SWIRM structure forms a compact HTH-related fold comprising five alpha-helices, which best resembles the Swi3 SWIRM structure, among the known SWIRM structures. The MYSM1 and Swi3 SWIRM structures are more similar to the LSD1 structure than the Ada2alpha structure. The SWIRM domains of MYSM1 and LSD1 lacked DNA binding activity, while those of Ada2alpha and the human Swi3 counterpart, SMARCC2, bound DNA. The dissimilarity in the DNA-binding ability of the MYSM1 and SMARCC2 SWIRM domains might be due to a couple of amino acid differences in the last helix. These results indicate that the SWIRM family has indeed diverged into three structural subfamilies (Swi3/MYSM1, LSD1, and Ada2 types), and that the Swi3/MYSM1-type subfamily has further diverged into two functionally distinct groups. We also solved the structure of the SANT domain of MYSM1, and demonstrated that it bound DNA with a similar mode to that of the c-Myb DNA-binding domain.

About this StructureAbout this Structure

2CU7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structural and functional differences of SWIRM domain subtypes., Yoneyama M, Tochio N, Umehara T, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Matsuda T, Watanabe S, Tomo Y, Nishimura Y, Harada T, Terada T, Shirouzu M, Hayashizaki Y, Ohara O, Tanaka A, Kigawa T, Yokoyama S, J Mol Biol. 2007 May 25;369(1):222-38. Epub 2007 Mar 19. PMID:17428495

Page seeded by OCA on Thu Mar 20 16:19:53 2008

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OCA

@@ Line 1: / Line 1: @@
-[[Image:2cu7.gif|left|200px]]<br /><applet load="2cu7" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2cu7.gif|left|200px]]
-caption="2cu7" />
-'''Solution structure of the SANT domain of human KIAA1915 protein'''<br />
+ {{Structure
+|PDB= 2cu7 |SIZE=350|CAPTION= <scene name='initialview01'>2cu7</scene>
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE= KIAA1915 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''Solution structure of the SANT domain of human KIAA1915 protein'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-CU7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CU7 OCA].
+CU7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CU7 OCA].
 ==Reference==
-Structural and functional differences of SWIRM domain subtypes., Yoneyama M, Tochio N, Umehara T, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Matsuda T, Watanabe S, Tomo Y, Nishimura Y, Harada T, Terada T, Shirouzu M, Hayashizaki Y, Ohara O, Tanaka A, Kigawa T, Yokoyama S, J Mol Biol. 2007 May 25;369(1):222-38. Epub 2007 Mar 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17428495 17428495]
+Structural and functional differences of SWIRM domain subtypes., Yoneyama M, Tochio N, Umehara T, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Matsuda T, Watanabe S, Tomo Y, Nishimura Y, Harada T, Terada T, Shirouzu M, Hayashizaki Y, Ohara O, Tanaka A, Kigawa T, Yokoyama S, J Mol Biol. 2007 May 25;369(1):222-38. Epub 2007 Mar 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17428495 17428495]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 24: / Line 33: @@
 [[Category: Yoneyama, M.]]
 [[Category: dna binding]]
-[[Category: national project on protein structural and functional analyses]]
+[[Category: national project on protein structural and functional analyse]]
 [[Category: nppsfa]]
 [[Category: nuclear protein]]
@@ Line 31: / Line 40: @@
 [[Category: rsgi]]
 [[Category: sant domain]]
-[[Category: structural genomics]]
+[[Category: structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:52:30 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:19:53 2008''