4ljo: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ljo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ljo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ljo RCSB], [http://www.ebi.ac.uk/pdbsum/4ljo PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ljo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ljo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ljo RCSB], [http://www.ebi.ac.uk/pdbsum/4ljo PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/RNF31_HUMAN RNF31_HUMAN]] E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('M-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.<ref>PMID:17006537</ref> <ref>PMID:20005846</ref> <ref>PMID:19136968</ref> <ref>PMID:21455173</ref> <ref>PMID:21455180</ref> <ref>PMID:21455181</ref> <ref>PMID:22863777</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Brown, N R | [[Category: Brown, N R]] | ||
[[Category: Christodoulou, E | [[Category: Christodoulou, E]] | ||
[[Category: Howell, S | [[Category: Howell, S]] | ||
[[Category: M G., Koliopoulos | [[Category: M G., Koliopoulos]] | ||
[[Category: Morris-Davies, A C | [[Category: Morris-Davies, A C]] | ||
[[Category: Rana, R R | [[Category: Rana, R R]] | ||
[[Category: Rittinger, K | [[Category: Rittinger, K]] | ||
[[Category: Stieglitz, B | [[Category: Stieglitz, B]] | ||
[[Category: E3 ligase]] | [[Category: E3 ligase]] | ||
[[Category: E3 ligase-ubiquitin complex]] | [[Category: E3 ligase-ubiquitin complex]] | ||