4bad: Difference between revisions

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-[[Image:4bad.png|left|200px]]
+==Hen egg-white lysozyme structure in complex with the europium tris- hydroxymethyltriazoledipicolinate complex at 1.35 A resolution.==
+<StructureSection load='4bad' size='340' side='right' caption='[[4bad]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4bad]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BAD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BAD FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EU3:EUROPIUM+(III)+ION'>EU3</scene>, <scene name='pdbligand=HM6:4-(4-(HYDROXYMETHYL)-1H-1,2,3-TRIAZOL-1-YL)PYRIDINE-2,6-DICARBOXYLIC+ACID'>HM6</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bad OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bad RCSB], [http://www.ebi.ac.uk/pdbsum/4bad PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+New trisdipicolinic acid-lanthanide complexes are reported as phasing agents for X-ray crystallography of proteins. It is demonstrated that CuAAC modifications allow protein co-crystallization with low concentration of lanthanide complexes leading to an accurate structure determination.
-{{STRUCTURE_4bad|  PDB=4bad  |  SCENE=  }}
+Clicked europium dipicolinate complexes for protein X-ray structure determination.,Talon R, Nauton L, Canet JL, Kahn R, Girard E, Gautier A Chem Commun (Camb). 2012 Nov 12;48(97):11886-8. doi: 10.1039/c2cc36982f. PMID:23123834<ref>PMID:23123834</ref>
-===Hen egg-white lysozyme structure in complex with the europium tris- hydroxymethyltriazoledipicolinate complex at 1.35 A resolution.===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_23123834}}
+==See Also==
+*[[Lysozyme 3D structures|Lysozyme 3D structures]]
-==About this Structure==
+== References ==
-[[4bad]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BAD OCA].
+<references/>
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:018350532</ref><ref group="xtra">PMID:020606256</ref><references group="xtra"/>
+[[Category: Chick]]
-[[Category: Gallus gallus]]
 [[Category: Lysozyme]]
-[[Category: Gautier, A.]]
+[[Category: Gautier, A]]
-[[Category: Girard, E.]]
+[[Category: Girard, E]]
-[[Category: Kahn, R.]]
+[[Category: Kahn, R]]
-[[Category: Nauton, L.]]
+[[Category: Nauton, L]]
-[[Category: Talon, R.]]
+[[Category: Talon, R]]
 [[Category: Anomalous scattering]]
 [[Category: Click-chemistry]]