2boc: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2boc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOC FirstGlance]. <br> | <table><tr><td colspan='2'>[[2boc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOC FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=T1A:TETRAETHYLARSONIUM+ION'>T1A</scene>, <scene name='pdbligand=TL:THALLIUM+(I)+ION'>TL</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=T1A:TETRAETHYLARSONIUM+ION'>T1A</scene>, <scene name='pdbligand=TL:THALLIUM+(I)+ION'>TL</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bl8|1bl8]], [[1f6g|1f6g]], [[1j95|1j95]], [[1jq1|1jq1]], [[1jq2|1jq2]], [[1jvm|1jvm]], [[1k4c|1k4c]], [[1k4d|1k4d]], [[1r3i|1r3i]], [[1r3j|1r3j]], [[1r3k|1r3k]], [[1r3l|1r3l]], [[1s5h|1s5h]], [[2bob|2bob]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bl8|1bl8]], [[1f6g|1f6g]], [[1j95|1j95]], [[1jq1|1jq1]], [[1jq2|1jq2]], [[1jvm|1jvm]], [[1k4c|1k4c]], [[1k4d|1k4d]], [[1r3i|1r3i]], [[1r3j|1r3j]], [[1r3k|1r3k]], [[1r3l|1r3l]], [[1s5h|1s5h]], [[2bob|2bob]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2boc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2boc RCSB], [http://www.ebi.ac.uk/pdbsum/2boc PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2boc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2boc RCSB], [http://www.ebi.ac.uk/pdbsum/2boc PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Streptomyces lividans]] | [[Category: Streptomyces lividans]] | ||
[[Category: Focia, P J | [[Category: Focia, P J]] | ||
[[Category: Gross, A | [[Category: Gross, A]] | ||
[[Category: Lenaeus, M J | [[Category: Lenaeus, M J]] | ||
[[Category: Vamvouka, M | [[Category: Vamvouka, M]] | ||
[[Category: Immune system-transport protein complex]] | [[Category: Immune system-transport protein complex]] | ||
[[Category: Immune system/transport protein]] | [[Category: Immune system/transport protein]] | ||
Revision as of 12:32, 25 December 2014
POTASSIUM CHANNEL KCSA-FAB COMPLEX IN THALLIUM WITH TETRAETHYLARSONIUM (TEAS)POTASSIUM CHANNEL KCSA-FAB COMPLEX IN THALLIUM WITH TETRAETHYLARSONIUM (TEAS)
Structural highlights
Function[KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedPotassium channels catalyze the selective transfer of potassium across the cell membrane and are essential for setting the resting potential in cells, controlling heart rate and modulating the firing pattern in neurons. Tetraethylammonium (TEA) blocks ion conduction through potassium channels in a voltage-dependent manner from both sides of the membrane. Here we show the structural basis of TEA blockade by cocrystallizing the prokaryotic potassium channel KcsA with two selective TEA analogs. TEA binding at both sites alters ion occupancy in the selectivity filter; these findings underlie the mutual destabilization and voltage-dependence of TEA blockade. We propose that TEA blocks potassium channels by acting as a potassium analog at the dehydration transition step during permeation. Structural basis of TEA blockade in a model potassium channel.,Lenaeus MJ, Vamvouka M, Focia PJ, Gross A Nat Struct Mol Biol. 2005 May;12(5):454-9. Epub 2005 Apr 24. PMID:15852022[2] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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