4i3p: Difference between revisions

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{{STRUCTURE_4i3p|  PDB=4i3p  |  SCENE=  }}
==1.96 angstrom x-ray crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase bound with 3-aminosalicylic acid from cupraavidus metallidurans==
===1.96 angstrom x-ray crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase bound with 3-aminosalicylic acid from cupraavidus metallidurans===
<StructureSection load='4i3p' size='340' side='right' caption='[[4i3p]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4i3p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cupriavidus_metallidurans_ch34 Cupriavidus metallidurans ch34]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I3P FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CW:3-AMINO-2-HYDROXYBENZOIC+ACID'>1CW</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cupriavidus metallidurans, nbaC, Rmet_5193 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=266264 Cupriavidus metallidurans CH34])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxyanthranilate_3,4-dioxygenase 3-hydroxyanthranilate 3,4-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.6 1.13.11.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i3p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i3p RCSB], [http://www.ebi.ac.uk/pdbsum/4i3p PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/3HAO_RALME 3HAO_RALME]] Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.<ref>PMID:15909977</ref>   
[[http://www.uniprot.org/uniprot/3HAO_RALME 3HAO_RALME]] Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.<ref>PMID:15909977</ref>   
 
== References ==
==About this Structure==
<references/>
[[4i3p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I3P OCA].
__TOC__
 
</StructureSection>
==Reference==
<references group="xtra"/><references/>
[[Category: 3-hydroxyanthranilate 3,4-dioxygenase]]
[[Category: 3-hydroxyanthranilate 3,4-dioxygenase]]
[[Category: Liu, A.]]
[[Category: Cupriavidus metallidurans ch34]]
[[Category: Liu, F.]]
[[Category: Liu, A]]
[[Category: Liu, F]]
[[Category: Bi-cupin iron-binding]]
[[Category: Bi-cupin iron-binding]]
[[Category: Dioxygenase]]
[[Category: Dioxygenase]]
[[Category: Oxioreductase-substrate complex]]
[[Category: Oxioreductase-substrate complex]]

Revision as of 12:25, 25 December 2014

1.96 angstrom x-ray crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase bound with 3-aminosalicylic acid from cupraavidus metallidurans1.96 angstrom x-ray crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase bound with 3-aminosalicylic acid from cupraavidus metallidurans

Structural highlights

4i3p is a 1 chain structure with sequence from Cupriavidus metallidurans ch34. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:Cupriavidus metallidurans, nbaC, Rmet_5193 (Cupriavidus metallidurans CH34)
Activity:3-hydroxyanthranilate 3,4-dioxygenase, with EC number 1.13.11.6
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[3HAO_RALME] Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.[1]

References

  1. ↑ Colabroy KL, Zhai H, Li T, Ge Y, Zhang Y, Liu A, Ealick SE, McLafferty FW, Begley TP. The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate. Biochemistry. 2005 May 31;44(21):7623-31. PMID:15909977 doi:http://dx.doi.org/10.1021/bi0473455

4i3p, resolution 1.96Å

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