1hn3: Difference between revisions
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hn3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hn3 RCSB], [http://www.ebi.ac.uk/pdbsum/1hn3 PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hn3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hn3 RCSB], [http://www.ebi.ac.uk/pdbsum/1hn3 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CD2A2_MOUSE CD2A2_MOUSE]] Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination (By similarity). Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform 4 may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.<ref>PMID:8521522</ref> <ref>PMID:9393858</ref> <ref>PMID:9529248</ref> <ref>PMID:10359817</ref> <ref>PMID:15361884</ref> <ref>PMID:15567177</ref> <ref>PMID:15601844</ref> <ref>PMID:16713577</ref> <ref>PMID:17936562</ref> <ref>PMID:15105443</ref> <ref>PMID:9012842</ref> [UniProtKB:Q8N726] | |||
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== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||