2iir: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2iir]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IIR FirstGlance]. <br>
<table><tr><td colspan='2'>[[2iir]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IIR FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g99|1g99]], [[1tuu|1tuu]], [[1tuy|1tuy]]</td></tr>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g99|1g99]], [[1tuu|1tuu]], [[1tuy|1tuy]]</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ack ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ack ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iir OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iir RCSB], [http://www.ebi.ac.uk/pdbsum/2iir PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iir OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iir RCSB], [http://www.ebi.ac.uk/pdbsum/2iir PDBsum]</span></td></tr>
<table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ACKA_THEMA ACKA_THEMA]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Phosphorylates propionate (54%) in addition to acetate (100%). Uses GTP (100%), ITP (163%), UTP (56%), and CTP (21%) as phosphoryl donors in addition to ATP (100%).<ref>PMID:10074080</ref> 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Acetate kinase]]
[[Category: Acetate kinase]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Hasson, M S.]]
[[Category: Hasson, M S]]
[[Category: Mukhopadhyay, S.]]
[[Category: Mukhopadhyay, S]]
[[Category: Sanders, D A.]]
[[Category: Sanders, D A]]
[[Category: Acetate kinase]]
[[Category: Thermotoga maritima]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 11:42, 25 December 2014

Acetate kinase from a hypothermophile Thermotoga maritimaAcetate kinase from a hypothermophile Thermotoga maritima

Structural highlights

2iir is a 10 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:ack (Thermotoga maritima)
Activity:Acetate kinase, with EC number 2.7.2.1
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[ACKA_THEMA] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Phosphorylates propionate (54%) in addition to acetate (100%). Uses GTP (100%), ITP (163%), UTP (56%), and CTP (21%) as phosphoryl donors in addition to ATP (100%).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Bock AK, Glasemacher J, Schmidt R, Schonheit P. Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima. J Bacteriol. 1999 Mar;181(6):1861-7. PMID:10074080

2iir, resolution 3.30Å

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