2wi2: Difference between revisions

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 == Structural highlights ==
 <table><tr><td colspan='2'>[[2wi2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WI2 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=ZZ3:4-METHYL-6-(METHYLSULFANYL)-1,3,5-TRIAZIN-2-AMINE'>ZZ3</scene><br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=ZZ3:4-METHYL-6-(METHYLSULFANYL)-1,3,5-TRIAZIN-2-AMINE'>ZZ3</scene></td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cdd|2cdd]], [[1yes|1yes]], [[1uy9|1uy9]], [[1byq|1byq]], [[1osf|1osf]], [[2bsm|2bsm]], [[1uy8|1uy8]], [[2bug|2bug]], [[2uwd|2uwd]], [[2bt0|2bt0]], [[1yer|1yer]], [[1uyg|1uyg]], [[2bz5|2bz5]], [[2ccu|2ccu]], [[2ccs|2ccs]], [[1uyi|1uyi]], [[1yc3|1yc3]], [[1uyf|1uyf]], [[1uyd|1uyd]], [[2byi|2byi]], [[1uy6|1uy6]], [[2vci|2vci]], [[2vcj|2vcj]], [[1yc4|1yc4]], [[2c2l|2c2l]], [[1uyk|1uyk]], [[1uyh|1uyh]], [[2cct|2cct]], [[1uye|1uye]], [[1uyl|1uyl]], [[1yc1|1yc1]], [[1uy7|1uy7]], [[1uyc|1uyc]], [[1yet|1yet]], [[2jjc|2jjc]], [[2byh|2byh]], [[2wi4|2wi4]], [[2wi7|2wi7]], [[2wi6|2wi6]], [[2wi3|2wi3]], [[2wi1|2wi1]], [[2wi5|2wi5]]</td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cdd|2cdd]], [[1yes|1yes]], [[1uy9|1uy9]], [[1byq|1byq]], [[1osf|1osf]], [[2bsm|2bsm]], [[1uy8|1uy8]], [[2bug|2bug]], [[2uwd|2uwd]], [[2bt0|2bt0]], [[1yer|1yer]], [[1uyg|1uyg]], [[2bz5|2bz5]], [[2ccu|2ccu]], [[2ccs|2ccs]], [[1uyi|1uyi]], [[1yc3|1yc3]], [[1uyf|1uyf]], [[1uyd|1uyd]], [[2byi|2byi]], [[1uy6|1uy6]], [[2vci|2vci]], [[2vcj|2vcj]], [[1yc4|1yc4]], [[2c2l|2c2l]], [[1uyk|1uyk]], [[1uyh|1uyh]], [[2cct|2cct]], [[1uye|1uye]], [[1uyl|1uyl]], [[1yc1|1yc1]], [[1uy7|1uy7]], [[1uyc|1uyc]], [[1yet|1yet]], [[2jjc|2jjc]], [[2byh|2byh]], [[2wi4|2wi4]], [[2wi7|2wi7]], [[2wi6|2wi6]], [[2wi3|2wi3]], [[2wi1|2wi1]], [[2wi5|2wi5]]</td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wi2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wi2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wi2 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wi2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wi2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wi2 PDBsum]</span></td></tr>
-<table>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Barril, X.]]
+[[Category: Barril, X]]
-[[Category: Borgognoni, J.]]
+[[Category: Borgognoni, J]]
-[[Category: Brough, P A.]]
+[[Category: Brough, P A]]
-[[Category: Chene, P.]]
+[[Category: Chene, P]]
-[[Category: Davies, N G.M.]]
+[[Category: Davies, N G.M]]
-[[Category: Davis, B.]]
+[[Category: Davis, B]]
-[[Category: Drysdale, M J.]]
+[[Category: Drysdale, M J]]
-[[Category: Dymock, B.]]
+[[Category: Dymock, B]]
-[[Category: Eccles, S A.]]
+[[Category: Eccles, S A]]
-[[Category: Fromont, C.]]
+[[Category: Fromont, C]]
-[[Category: Garcia-Echeverria, C.]]
+[[Category: Garcia-Echeverria, C]]
-[[Category: Hayes, A.]]
+[[Category: Hayes, A]]
-[[Category: Hubbard, R E.]]
+[[Category: Hubbard, R E]]
-[[Category: Jordan, A M.]]
+[[Category: Jordan, A M]]
-[[Category: Massey, A.]]
+[[Category: Massey, A]]
-[[Category: Merret, A.]]
+[[Category: Merret, A]]
-[[Category: Padfield, A.]]
+[[Category: Padfield, A]]
-[[Category: Parsons, R.]]
+[[Category: Parsons, R]]
-[[Category: Radimerski, T.]]
+[[Category: Radimerski, T]]
-[[Category: Raynaud, F I.]]
+[[Category: Raynaud, F I]]
-[[Category: Robertson, A.]]
+[[Category: Robertson, A]]
-[[Category: Roughley, S D.]]
+[[Category: Roughley, S D]]
-[[Category: Rugaard-Jensen, M.]]
+[[Category: Rugaard-Jensen, M]]
-[[Category: Schoepfer, J.]]
+[[Category: Schoepfer, J]]
-[[Category: Simmonite, H.]]
+[[Category: Simmonite, H]]
-[[Category: Surgenor, A.]]
+[[Category: Surgenor, A]]
-[[Category: Valenti, M.]]
+[[Category: Valenti, M]]
-[[Category: Walls, S.]]
+[[Category: Walls, S]]
-[[Category: Webb, P.]]
+[[Category: Webb, P]]
-[[Category: Wood, M.]]
+[[Category: Wood, M]]
-[[Category: Workman, P.]]
+[[Category: Workman, P]]
-[[Category: Wright, L M.]]
+[[Category: Wright, L M]]
 [[Category: Atp-binding]]
 [[Category: Atpase]]