2rep: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 3: Line 3:
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2rep]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2REP FirstGlance]. <br>
<table><tr><td colspan='2'>[[2rep]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2REP FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene><br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIFC1, HSET, KNSL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIFC1, HSET, KNSL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rep OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rep RCSB], [http://www.ebi.ac.uk/pdbsum/2rep PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rep OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rep RCSB], [http://www.ebi.ac.uk/pdbsum/2rep PDBsum]</span></td></tr>
<table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KIFC1_HUMAN KIFC1_HUMAN]] Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles.<ref>PMID:15843429</ref> 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 20: Line 22:
==See Also==
==See Also==
*[[Kinesin|Kinesin]]
*[[Kinesin|Kinesin]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev, A]]
[[Category: Brothers, G.]]
[[Category: Brothers, G]]
[[Category: Edwards, A M.]]
[[Category: Edwards, A M]]
[[Category: He, H.]]
[[Category: He, H]]
[[Category: Landry, R.]]
[[Category: Landry, R]]
[[Category: Park, H.]]
[[Category: Park, H]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Structural genomic]]
[[Category: Shen, Y.]]
[[Category: Shen, Y]]
[[Category: Sundstrom, M.]]
[[Category: Sundstrom, M]]
[[Category: Tempel, W.]]
[[Category: Tempel, W]]
[[Category: Wang, J.]]
[[Category: Wang, J]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J]]
[[Category: Zhu, H.]]
[[Category: Zhu, H]]
[[Category: Adp]]
[[Category: Adp]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
Line 51: Line 55:
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Structural genomics consortium]]

Revision as of 10:16, 25 December 2014

Crystal structure of the motor domain of human kinesin family member C1Crystal structure of the motor domain of human kinesin family member C1

Structural highlights

2rep is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Gene:KIFC1, HSET, KNSL2 (Homo sapiens)
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[KIFC1_HUMAN] Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Zhu C, Zhao J, Bibikova M, Leverson JD, Bossy-Wetzel E, Fan JB, Abraham RT, Jiang W. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol Biol Cell. 2005 Jul;16(7):3187-99. Epub 2005 Apr 20. PMID:15843429 doi:http://dx.doi.org/10.1091/mbc.E05-02-0167

2rep, resolution 2.60Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Jaime Prilusky
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2rep&oldid=2259330"