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[[ | ==Identification and structural characterization of PDE10 fragment inhibitors== | ||
<StructureSection load='4ajf' size='340' side='right' caption='[[4ajf]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ajf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AJF FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F03:N-(4-OXO-3H-QUINAZOLIN-2-YL)ACETAMIDE'>F03</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lrb|1lrb]], [[2wey|2wey]], [[2y0j|2y0j]], [[4ael|4ael]], [[4ajd|4ajd]], [[4ajg|4ajg]], [[4ajm|4ajm]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ajf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ajf RCSB], [http://www.ebi.ac.uk/pdbsum/4ajf PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | |||
==See Also== | |||
*[[Phosphodiesterase|Phosphodiesterase]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
== | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Aharony, D | [[Category: Aharony, D]] | ||
[[Category: Akerud, T | [[Category: Akerud, T]] | ||
[[Category: Albert, J S | [[Category: Albert, J S]] | ||
[[Category: Back, E | [[Category: Back, E]] | ||
[[Category: Geschwindner, S | [[Category: Geschwindner, S]] | ||
[[Category: Hillertz, P | [[Category: Hillertz, P]] | ||
[[Category: Horsefeld, R | [[Category: Horsefeld, R]] | ||
[[Category: Johansson, P | [[Category: Johansson, P]] | ||
[[Category: Scott, C | [[Category: Scott, C]] | ||
[[Category: Spadola, L | [[Category: Spadola, L]] | ||
[[Category: Spear, N | [[Category: Spear, N]] | ||
[[Category: Tian, G | [[Category: Tian, G]] | ||
[[Category: Tigerstrom, A | [[Category: Tigerstrom, A]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 10:02, 25 December 2014
Identification and structural characterization of PDE10 fragment inhibitorsIdentification and structural characterization of PDE10 fragment inhibitors
Structural highlights
Function[PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.[1] See AlsoReferences |
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