1s7h: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s7h RCSB], [http://www.ebi.ac.uk/pdbsum/1s7h PDBsum], [http://www.topsan.org/Proteins/MCSG/1s7h TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s7h RCSB], [http://www.ebi.ac.uk/pdbsum/1s7h PDBsum], [http://www.topsan.org/Proteins/MCSG/1s7h TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/YKOF_BACSU YKOF_BACSU]] Part of the ABC transporter complex YkoCDEF that could transport hydroxymethylpyrimidine (HMP) and/or thiamine. Could also transport other HMP-containing products. Binds thiamine via its HMP moiety.<ref>PMID:12376536</ref> <ref>PMID:16291685</ref> 
== References ==
<references/>
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Revision as of 09:56, 25 December 2014

Structural Genomics, 2.2A crystal structure of protein YKOF from Bacillus subtilisStructural Genomics, 2.2A crystal structure of protein YKOF from Bacillus subtilis

Structural highlights

1s7h is a 4 chain structure with sequence from "bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:YKOF ("Bacillus globigii" Migula 1900)
Resources:FirstGlance, OCA, RCSB, PDBsum, TOPSAN

Function

[YKOF_BACSU] Part of the ABC transporter complex YkoCDEF that could transport hydroxymethylpyrimidine (HMP) and/or thiamine. Could also transport other HMP-containing products. Binds thiamine via its HMP moiety.[1] [2]

References

  1. ↑ Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS. Comparative genomics of thiamin biosynthesis in procaryotes. New genes and regulatory mechanisms. J Biol Chem. 2002 Dec 13;277(50):48949-59. Epub 2002 Oct 9. PMID:12376536 doi:http://dx.doi.org/10.1074/jbc.M208965200
  2. ↑ Schyns G, Potot S, Geng Y, Barbosa TM, Henriques A, Perkins JB. Isolation and characterization of new thiamine-deregulated mutants of Bacillus subtilis. J Bacteriol. 2005 Dec;187(23):8127-36. PMID:16291685 doi:http://dx.doi.org/187/23/8127

1s7h, resolution 2.20Å

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