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==Crystal structure of the 3-MBT repeat domain of L3MBTL3 and UNC2533 complex== | |||
<StructureSection load='4l59' size='340' side='right' caption='[[4l59]], [[Resolution|resolution]] 2.29Å' scene=''> | |||
== Structural highlights == | |||
==Function== | <table><tr><td colspan='2'>[[4l59]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L59 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1VZ:4-(PYRROLIDIN-1-YL)-1-{4-[2-(PYRROLIDIN-1-YL)ETHYL]PHENYL}PIPERIDINE'>1VZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">L3MBTL3, KIAA1798, MBT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l59 RCSB], [http://www.ebi.ac.uk/pdbsum/4l59 PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/LMBL3_HUMAN LMBL3_HUMAN]] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity). | [[http://www.uniprot.org/uniprot/LMBL3_HUMAN LMBL3_HUMAN]] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity). | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Baughman, B M | [[Category: Baughman, B M]] | ||
[[Category: Bountra, C | [[Category: Bountra, C]] | ||
[[Category: Brown, P J | [[Category: Brown, P J]] | ||
[[Category: Camerino, M A | [[Category: Camerino, M A]] | ||
[[Category: Dickson, B M | [[Category: Dickson, B M]] | ||
[[Category: Dong, A | [[Category: Dong, A]] | ||
[[Category: Edwards, A M | [[Category: Edwards, A M]] | ||
[[Category: Frye, S V | [[Category: Frye, S V]] | ||
[[Category: Graslund, S | [[Category: Graslund, S]] | ||
[[Category: James, L I | [[Category: James, L I]] | ||
[[Category: Janzen, W P | [[Category: Janzen, W P]] | ||
[[Category: Kireev, D B | [[Category: Kireev, D B]] | ||
[[Category: Norris, J L | [[Category: Norris, J L]] | ||
[[Category: Ravichandran, M | [[Category: Ravichandran, M]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Zhong, N | [[Category: Zhong, N]] | ||
[[Category: 3-mbt repeat domain]] | [[Category: 3-mbt repeat domain]] | ||
[[Category: L3mbtl3]] | [[Category: L3mbtl3]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Unc2533]] | [[Category: Unc2533]] | ||
Revision as of 09:02, 25 December 2014
Crystal structure of the 3-MBT repeat domain of L3MBTL3 and UNC2533 complexCrystal structure of the 3-MBT repeat domain of L3MBTL3 and UNC2533 complex
Structural highlights
Function[LMBL3_HUMAN] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity). |
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