3rae: Difference between revisions

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[[Image:3rae.png|left|200px]]
==Quinolone(Levofloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae==
 
<StructureSection load='3rae' size='340' side='right' caption='[[3rae]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
{{STRUCTURE_3rae|  PDB=3rae  |  SCENE=  }}
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3rae]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RAE FirstGlance]. <br>
===Quinolone(Levofloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae===
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFX:(3S)-9-FLUORO-3-METHYL-10-(4-METHYLPIPERAZIN-1-YL)-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC+ACID'>LFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2nov|2nov]], [[3foe|3foe]], [[3fof|3fof]], [[3k9f|3k9f]], [[3ksa|3ksa]], [[3ksb|3ksb]], [[3ltn|3ltn]], [[3rad|3rad]], [[3raf|3raf]]</td></tr>
 
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">parC, SP_0855 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae]), parE, SP_0852 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rae OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rae RCSB], [http://www.ebi.ac.uk/pdbsum/3rae PDBsum]</span></td></tr>
[[3rae]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAE OCA].  
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref>  [[http://www.uniprot.org/uniprot/PARE_STRPN PARE_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> 


==See Also==
==See Also==
*[[Topoisomerase|Topoisomerase]]
*[[Topoisomerase|Topoisomerase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
[[Category: Fisher, L M.]]
[[Category: Fisher, L M]]
[[Category: Laponogov, I.]]
[[Category: Laponogov, I]]
[[Category: McAuley, K E.]]
[[Category: McAuley, K E]]
[[Category: Pan, X S.]]
[[Category: Pan, X S]]
[[Category: Sanderson, M R.]]
[[Category: Sanderson, M R]]
[[Category: Veselkov, D A.]]
[[Category: Veselkov, D A]]
[[Category: Isomerase-dna-antibiotic complex]]
[[Category: Isomerase-dna-antibiotic complex]]
[[Category: Levofloxacin]]
[[Category: Levofloxacin]]
[[Category: Protein-dna cleavage complex]]
[[Category: Protein-dna cleavage complex]]
[[Category: Topoisomerase iia]]
[[Category: Topoisomerase iia]]

Revision as of 09:02, 25 December 2014

Quinolone(Levofloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniaeQuinolone(Levofloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae

Structural highlights

3rae is a 8 chain structure with sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:parC, SP_0855 (Streptococcus pneumoniae), parE, SP_0852 (Streptococcus pneumoniae)
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[PARC_STRPN] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.[1] [2] [PARE_STRPN] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.[3] [4]

See Also

References

  1. ↑ Laponogov I, Veselkov DA, Sohi MK, Pan XS, Achari A, Yang C, Ferrara JD, Fisher LM, Sanderson MR. Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target. PLoS ONE. 2007 Mar 21;2(3):e301. PMID:17375187 doi:10.1371/journal.pone.0000301
  2. ↑ Laponogov I, Pan XS, Veselkov DA, McAuley KE, Fisher LM, Sanderson MR. Structural basis of gate-DNA breakage and resealing by type II topoisomerases. PLoS One. 2010 Jun 28;5(6):e11338. PMID:20596531 doi:10.1371/journal.pone.0011338
  3. ↑ Laponogov I, Veselkov DA, Sohi MK, Pan XS, Achari A, Yang C, Ferrara JD, Fisher LM, Sanderson MR. Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target. PLoS ONE. 2007 Mar 21;2(3):e301. PMID:17375187 doi:10.1371/journal.pone.0000301
  4. ↑ Laponogov I, Pan XS, Veselkov DA, McAuley KE, Fisher LM, Sanderson MR. Structural basis of gate-DNA breakage and resealing by type II topoisomerases. PLoS One. 2010 Jun 28;5(6):e11338. PMID:20596531 doi:10.1371/journal.pone.0011338

3rae, resolution 2.90Å

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