2x7v: Difference between revisions
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<StructureSection load='2x7v' size='340' side='right' caption='[[2x7v]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2x7v' size='340' side='right' caption='[[2x7v]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2x7v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima_msb8 Thermotoga maritima msb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7V OCA]. <br> | <table><tr><td colspan='2'>[[2x7v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima_msb8 Thermotoga maritima msb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X7V FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2x7w|2x7w]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2x7w|2x7w]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxyribonuclease_IV_(phage-T(4)-induced) Deoxyribonuclease IV (phage-T(4)-induced)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.21.2 3.1.21.2] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x7v RCSB], [http://www.ebi.ac.uk/pdbsum/2x7v PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x7v RCSB], [http://www.ebi.ac.uk/pdbsum/2x7v PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/END4_THEMA END4_THEMA]] Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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Structure of the endonuclease IV homologue from Thermotoga maritima in the presence of active-site divalent metal ions.,Tomanicek SJ, Hughes RC, Ng JD, Coates L Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt, 9):1003-12. Epub 2010 Aug 21. PMID:20823514<ref>PMID:20823514</ref> | Structure of the endonuclease IV homologue from Thermotoga maritima in the presence of active-site divalent metal ions.,Tomanicek SJ, Hughes RC, Ng JD, Coates L Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt, 9):1003-12. Epub 2010 Aug 21. PMID:20823514<ref>PMID:20823514</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Thermotoga maritima msb8]] | [[Category: Thermotoga maritima msb8]] | ||
[[Category: Coates, L | [[Category: Coates, L]] | ||
[[Category: Hughes, R C | [[Category: Hughes, R C]] | ||
[[Category: Ng, J D | [[Category: Ng, J D]] | ||
[[Category: Tomanicek, S J | [[Category: Tomanicek, S J]] | ||
[[Category: Dna damage]] | [[Category: Dna damage]] | ||
[[Category: Dna repair]] | [[Category: Dna repair]] | ||