2bs0: Difference between revisions
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[[Image:2bs0.gif|left|200px]] | [[Image:2bs0.gif|left|200px]] | ||
'''MS2 (N87AE89K MUTANT)- VARIANT QBETA RNA HAIRPIN COMPLEX''' | {{Structure | ||
|PDB= 2bs0 |SIZE=350|CAPTION= <scene name='initialview01'>2bs0</scene>, resolution 2.45Å | |||
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'''MS2 (N87AE89K MUTANT)- VARIANT QBETA RNA HAIRPIN COMPLEX''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2BS0 is a [ | 2BS0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Enterobacterio_phage_ms2 Enterobacterio phage ms2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BS0 OCA]. | ||
==Reference== | ==Reference== | ||
Structural basis of RNA binding discrimination between bacteriophages Qbeta and MS2., Horn WT, Tars K, Grahn E, Helgstrand C, Baron AJ, Lago H, Adams CJ, Peabody DS, Phillips SE, Stonehouse NJ, Liljas L, Stockley PG, Structure. 2006 Mar;14(3):487-95. PMID:[http:// | Structural basis of RNA binding discrimination between bacteriophages Qbeta and MS2., Horn WT, Tars K, Grahn E, Helgstrand C, Baron AJ, Lago H, Adams CJ, Peabody DS, Phillips SE, Stonehouse NJ, Liljas L, Stockley PG, Structure. 2006 Mar;14(3):487-95. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16531233 16531233] | ||
[[Category: Enterobacterio phage ms2]] | [[Category: Enterobacterio phage ms2]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: virus/viral protein/rna]] | [[Category: virus/viral protein/rna]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:05:56 2008'' | ||
Revision as of 17:05, 20 March 2008
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MS2 (N87AE89K MUTANT)- VARIANT QBETA RNA HAIRPIN COMPLEX
OverviewOverview
Sequence-specific interactions between RNA stem-loops and coat protein (CP) subunits play vital roles in the life cycles of the RNA bacteriophages, e.g., by allowing translational repression of their replicase cistrons and tagging their own RNA genomes for encapsidation. The CPs of bacteriophages Qbeta and MS2 each discriminate in favor of their cognate translational operators, even in the presence of closely related operators from other phages in vivo. Discrete mutations within the MS2 CP have been shown to relax this discrimination in vitro. We have determined the structures of eight complexes between such mutants and both MS2 and Qbeta stem-loops with X-ray crystallography. In conjunction with previously determined in vivo repression data, the structures enable us to propose the molecular basis for the discrimination mechanism.
About this StructureAbout this Structure
2BS0 is a Protein complex structure of sequences from Enterobacterio phage ms2. Full crystallographic information is available from OCA.
ReferenceReference
Structural basis of RNA binding discrimination between bacteriophages Qbeta and MS2., Horn WT, Tars K, Grahn E, Helgstrand C, Baron AJ, Lago H, Adams CJ, Peabody DS, Phillips SE, Stonehouse NJ, Liljas L, Stockley PG, Structure. 2006 Mar;14(3):487-95. PMID:16531233
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Enterobacterio phage ms2
- Protein complex
- Adams, C J.
- Baron, A J.
- Grahn, E.
- Helgstrand, C.
- Horn, W T.
- Lago, H.
- Liljas, L.
- Peabody, D S.
- Phillips, S E.V.
- Stockley, P G.
- Stonehouse, N J.
- Tars, K.
- Capsid
- Coplex (capsid protein-rna hairpin)
- Hairpin
- Icosahedral virus
- Levivirus
- Rna-binding
- Structural protein
- Virus coat protein
- Virus/viral protein/rna