2bop: Difference between revisions

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CRYSTAL STRUCTURE AT 1.7 ANGSTROMS OF THE BOVINE PAPILLOMAVIRUS-1 E2 DNA-BINDING DOMAIN BOUND TO ITS DNA TARGET

OverviewOverview

The dominant transcriptional regulator of the papillomaviruses, E2, binds to its specific DNA target through a previously unobserved dimeric antiparallel beta-barrel. The DNA is severely but smoothly bent over the barrel by the interaction of successive major grooves with a pair of symmetrically disposed alpha-helices. The specific interface is an 'interwoven' network of interactions where the identifying base pairs of the target contact more than one amino-acid side chain and the discriminating amino acids interact with more than one base pair.

About this StructureAbout this Structure

2BOP is a Single protein structure of sequence from Bovine papillomavirus type 1. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target., Hegde RS, Grossman SR, Laimins LA, Sigler PB, Nature. 1992 Oct 8;359(6395):505-12. PMID:1328886

Page seeded by OCA on Thu Mar 20 16:04:40 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2bop.gif|left|200px]]<br /><applet load="2bop" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2bop.gif|left|200px]]
-caption="2bop, resolution 1.700&Aring;" />
-'''CRYSTAL STRUCTURE AT 1.7 ANGSTROMS OF THE BOVINE PAPILLOMAVIRUS-1 E2 DNA-BINDING DOMAIN BOUND TO ITS DNA TARGET'''<br />
+ {{Structure
+|PDB= 2bop |SIZE=350|CAPTION= <scene name='initialview01'>2bop</scene>, resolution 1.700&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=YB:YTTERBIUM (III) ION'>YB</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''CRYSTAL STRUCTURE AT 1.7 ANGSTROMS OF THE BOVINE PAPILLOMAVIRUS-1 E2 DNA-BINDING DOMAIN BOUND TO ITS DNA TARGET'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-BOP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1] with <scene name='pdbligand=YB:'>YB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOP OCA].
+BOP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOP OCA].
 ==Reference==
-Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target., Hegde RS, Grossman SR, Laimins LA, Sigler PB, Nature. 1992 Oct 8;359(6395):505-12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1328886 1328886]
+Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target., Hegde RS, Grossman SR, Laimins LA, Sigler PB, Nature. 1992 Oct 8;359(6395):505-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1328886 1328886]
 [[Category: Bovine papillomavirus type 1]]
 [[Category: Single protein]]
@@ Line 21: / Line 30: @@
 [[Category: protein-dna complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:40:00 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:04:40 2008''