2bj6: Difference between revisions
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[[Image:2bj6.gif|left|200px]] | [[Image:2bj6.gif|left|200px]] | ||
'''CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID''' | {{Structure | ||
|PDB= 2bj6 |SIZE=350|CAPTION= <scene name='initialview01'>2bj6</scene>, resolution 2.60Å | |||
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+G'>AC1</scene> | |||
|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2BJ6 is a [ | 2BJ6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJ6 OCA]. | ||
==Reference== | ==Reference== | ||
Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid., Maier T, Przylas I, Strater N, Herdewijn P, Saenger W, J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:[http:// | Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid., Maier T, Przylas I, Strater N, Herdewijn P, Saenger W, J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15740130 15740130] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Herdewijn, P.]] | [[Category: Herdewijn, P.]] | ||
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[[Category: rna]] | [[Category: rna]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:02:37 2008'' | ||
Revision as of 17:02, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID
OverviewOverview
The crystal structure of a decameric HNA/RNA (HNA = 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid duplex between a naturally occurring nucleic acid and a strand, which is fully modified to contain a six-membered ring instead of ribose. The presence of four duplex helices in the asymmetric unit allows for a detailed discussion of hydration, which revealed a tighter spinelike backbone hydration for the HNA- than for the RNA-strands. The reinforced backbone hydration is suggested to contribute significantly to the exceptional stability of HNA-containing duplexes and might be one of the causes for the evolutionary preference for ribose-derived nucleic acids.
About this StructureAbout this Structure
2BJ6 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
ReferenceReference
Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid., Maier T, Przylas I, Strater N, Herdewijn P, Saenger W, J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:15740130
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