2bfq: Difference between revisions

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MACRO DOMAINS ARE ADP-RIBOSE BINDING MOLECULES

OverviewOverview

The ADP-ribosylation of proteins is an important post-translational modification that occurs in a variety of biological processes, including DNA repair, transcription, chromatin biology and long-term memory formation. Yet no protein modules are known that specifically recognize the ADP-ribose nucleotide. We provide biochemical and structural evidence that macro domains are high-affinity ADP-ribose binding modules. Our structural analysis reveals a conserved ligand binding pocket among the macro domain fold. Consistently, distinct human macro domains retain their ability to bind ADP-ribose. In addition, some macro domain proteins also recognize poly-ADP-ribose as a ligand. Our data suggest an important role for proteins containing macro domains in the biology of ADP-ribose.

About this StructureAbout this Structure

2BFQ is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

ReferenceReference

The macro domain is an ADP-ribose binding module., Karras GI, Kustatscher G, Buhecha HR, Allen MD, Pugieux C, Sait F, Bycroft M, Ladurner AG, EMBO J. 2005 Jun 1;24(11):1911-20. Epub 2005 May 19. PMID:15902274

Page seeded by OCA on Thu Mar 20 16:01:21 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2bfq.gif|left|200px]]<br /><applet load="2bfq" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2bfq.gif|left|200px]]
-caption="2bfq, resolution 1.5&Aring;" />
-'''MACRO DOMAINS ARE ADP-RIBOSE BINDING MOLECULES'''<br />
+ {{Structure
+|PDB= 2bfq |SIZE=350|CAPTION= <scene name='initialview01'>2bfq</scene>, resolution 1.5&Aring;
+|SITE= <scene name='pdbsite=AC1:Apr+Binding+Site+For+Chain+A'>AC1</scene>
+|LIGAND= <scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''MACRO DOMAINS ARE ADP-RIBOSE BINDING MOLECULES'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-BFQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus] with <scene name='pdbligand=APR:'>APR</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Apr+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BFQ OCA].
+BFQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BFQ OCA].
 ==Reference==
-The macro domain is an ADP-ribose binding module., Karras GI, Kustatscher G, Buhecha HR, Allen MD, Pugieux C, Sait F, Bycroft M, Ladurner AG, EMBO J. 2005 Jun 1;24(11):1911-20. Epub 2005 May 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15902274 15902274]
+The macro domain is an ADP-ribose binding module., Karras GI, Kustatscher G, Buhecha HR, Allen MD, Pugieux C, Sait F, Bycroft M, Ladurner AG, EMBO J. 2005 Jun 1;24(11):1911-20. Epub 2005 May 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15902274 15902274]
 [[Category: Archaeoglobus fulgidus]]
 [[Category: Single protein]]
@@ Line 27: / Line 36: @@
 [[Category: nucleotide]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:37:20 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:01:21 2008''