3vd0: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vd0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vd0 RCSB], [http://www.ebi.ac.uk/pdbsum/3vd0 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vd0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vd0 RCSB], [http://www.ebi.ac.uk/pdbsum/3vd0 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Ethayathulla, A S | [[Category: Ethayathulla, A S]] | ||
[[Category: Nguyen, S | [[Category: Nguyen, S]] | ||
[[Category: Tse, P W | [[Category: Tse, P W]] | ||
[[Category: Viadiu, H | [[Category: Viadiu, H]] | ||
[[Category: Antitumor protein-dna complex]] | [[Category: Antitumor protein-dna complex]] | ||
[[Category: Beta-immunoglobulin-like fold]] | [[Category: Beta-immunoglobulin-like fold]] | ||
Revision as of 06:18, 25 December 2014
structure of p73 DNA binding domain tetramer modulates p73 transactivationstructure of p73 DNA binding domain tetramer modulates p73 transactivation
Structural highlights
Function[P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.[1] [2] [3] Publication Abstract from PubMedThe transcription factor p73 triggers developmental pathways and overlaps stress-induced p53 transcriptional pathways. How p53-family response elements determine and regulate transcriptional specificity remains an unsolved problem. In this work, we have determined the first crystal structures of p73 DNA-binding domain tetramer bound to response elements with spacers of different length. The structure and function of the adaptable tetramer are determined by the distance between two half-sites. The structures with zero and one base-pair spacers show compact p73 DNA-binding domain tetramers with large tetramerization interfaces; a two base-pair spacer results in DNA unwinding and a smaller tetramerization interface, whereas a four base-pair spacer hinders tetramerization. Functionally, p73 is more sensitive to spacer length than p53, with one base-pair spacer reducing 90% of transactivation activity and longer spacers reducing transactivation to basal levels. Our results establish the quaternary structure of the p73 DNA-binding domain required as a scaffold to promote transactivation. Structure of p73 DNA-binding domain tetramer modulates p73 transactivation.,Ethayathulla AS, Tse PW, Monti P, Nguyen S, Inga A, Fronza G, Viadiu H Proc Natl Acad Sci U S A. 2012 Apr 2. PMID:22474346[4] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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