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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v3k RCSB], [http://www.ebi.ac.uk/pdbsum/3v3k PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v3k RCSB], [http://www.ebi.ac.uk/pdbsum/3v3k PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CASP9_HUMAN CASP9_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).<ref>PMID:15657060</ref> Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<ref>PMID:15657060</ref> [[http://www.uniprot.org/uniprot/Q8XAL7_ECO57 Q8XAL7_ECO57]] Effector protein that alters host cell physiology and promotes bacterial survival in host tissues. Inhibits the catalytic activity of human CASP4, CASP8 and CASP9, and thereby inhibits apoptosis of infected host cells.<ref>PMID:18279332</ref> <ref>PMID:23516580</ref> | |||
==See Also== | ==See Also== | ||
*[[Caspase|Caspase]] | *[[Caspase|Caspase]] | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 05:42, 25 December 2014
Human caspase 9 in complex with bacterial effector proteinHuman caspase 9 in complex with bacterial effector protein
Structural highlights
Function[CASP9_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).[1] Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.[2] [Q8XAL7_ECO57] Effector protein that alters host cell physiology and promotes bacterial survival in host tissues. Inhibits the catalytic activity of human CASP4, CASP8 and CASP9, and thereby inhibits apoptosis of infected host cells.[3] [4] See AlsoReferences
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