2b1e: Difference between revisions
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'''The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif''' | {{Structure | ||
|PDB= 2b1e |SIZE=350|CAPTION= <scene name='initialview01'>2b1e</scene>, resolution 2.0Å | |||
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'''The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2B1E is a [ | 2B1E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B1E OCA]. | ||
==Reference== | ==Reference== | ||
The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif., Dong G, Hutagalung AH, Fu C, Novick P, Reinisch KM, Nat Struct Mol Biol. 2005 Dec;12(12):1094-100. Epub 2005 Oct 26. PMID:[http:// | The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif., Dong G, Hutagalung AH, Fu C, Novick P, Reinisch KM, Nat Struct Mol Biol. 2005 Dec;12(12):1094-100. Epub 2005 Oct 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16249794 16249794] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: tethering complex]] | [[Category: tethering complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:56:24 2008'' | ||
Revision as of 16:56, 20 March 2008
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The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif
OverviewOverview
The exocyst is a large complex that is required for tethering vesicles at the final stages of the exocytic pathway in all eukaryotes. Here we present the structures of the Exo70p subunit of this complex and of the C-terminal domains of Exo84p, at 2.0-A and 2.85-A resolution, respectively. Exo70p forms a 160-A-long rod with a novel fold composed of contiguous alpha-helical bundles. The Exo84p C terminus also forms a long rod (80 A), which unexpectedly has the same fold as the Exo70p N terminus. Our structural results and our experimental observations concerning the interaction between Exo70p and other exocyst subunits or Rho3p GTPase are consistent with an architecture wherein exocyst subunits are composed of mostly helical modules strung together into long rods.
About this StructureAbout this Structure
2B1E is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
ReferenceReference
The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif., Dong G, Hutagalung AH, Fu C, Novick P, Reinisch KM, Nat Struct Mol Biol. 2005 Dec;12(12):1094-100. Epub 2005 Oct 26. PMID:16249794
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