3n2f: Difference between revisions
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==Crystal structure of the sodium-potassium pump== | |||
<StructureSection load='3n2f' size='340' side='right' caption='[[3n2f]], [[Resolution|resolution]] 4.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3n2f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N2F FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PHD:ASPARTYL+PHOSPHATE'>PHD</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3n23|3n23]], [[3kdp|3kdp]], [[3b9b|3b9b]]</td></tr> | |||
== | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sodium/potassium-exchanging_ATPase Sodium/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.9 3.6.3.9] </span></td></tr> | ||
[[3n2f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N2F OCA]. | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n2f RCSB], [http://www.ebi.ac.uk/pdbsum/3n2f PDBsum]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/AT1A1_PIG AT1A1_PIG]] This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. [[http://www.uniprot.org/uniprot/AT1B1_PIG AT1B1_PIG]] This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. | |||
==See Also== | ==See Also== | ||
*[[ATPase|ATPase]] | *[[ATPase|ATPase]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Sodium/potassium-exchanging ATPase]] | [[Category: Sodium/potassium-exchanging ATPase]] | ||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
[[Category: Esmann, M | [[Category: Esmann, M]] | ||
[[Category: Fedosova, N U | [[Category: Fedosova, N U]] | ||
[[Category: Laursen, M | [[Category: Laursen, M]] | ||
[[Category: Morth, J P | [[Category: Morth, J P]] | ||
[[Category: Nissen, P | [[Category: Nissen, P]] | ||
[[Category: Yatime, L | [[Category: Yatime, L]] | ||
[[Category: Cardiotonic steroid]] | [[Category: Cardiotonic steroid]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: P-type atpase]] | [[Category: P-type atpase]] | ||
[[Category: Sodium-potassium pump]] | [[Category: Sodium-potassium pump]] | ||