4jnd: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jnd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jnd RCSB], [http://www.ebi.ac.uk/pdbsum/4jnd PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jnd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jnd RCSB], [http://www.ebi.ac.uk/pdbsum/4jnd PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/FEM2_CAEEL FEM2_CAEEL]] Probable phosphatase involved in the regulation of sex determination. Plays an important role in regulating a pathway transducing a non-cell-autonomous signal to a nuclear transcription factor. Promotes apoptosis. Together with fem-3 associates with the CBC(fem-1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of tra-1.
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</StructureSection>
</StructureSection>

Revision as of 05:04, 25 December 2014

Structure of a C.elegans sex determining proteinStructure of a C.elegans sex determining protein

Structural highlights

4jnd is a 1 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:fem-2, T19C3.8 (Caenorhabditis elegans)
Activity:Phosphoprotein phosphatase, with EC number 3.1.3.16
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[FEM2_CAEEL] Probable phosphatase involved in the regulation of sex determination. Plays an important role in regulating a pathway transducing a non-cell-autonomous signal to a nuclear transcription factor. Promotes apoptosis. Together with fem-3 associates with the CBC(fem-1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of tra-1.

4jnd, resolution 1.65Å

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OCA