2xnb: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xnb RCSB], [http://www.ebi.ac.uk/pdbsum/2xnb PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xnb RCSB], [http://www.ebi.ac.uk/pdbsum/2xnb PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Cyclin-dependent kinase]] | [[Category: Cyclin-dependent kinase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Barnett, A L | [[Category: Barnett, A L]] | ||
[[Category: Blake, D G | [[Category: Blake, D G]] | ||
[[Category: Cooper, M | [[Category: Cooper, M]] | ||
[[Category: Fischer, P M | [[Category: Fischer, P M]] | ||
[[Category: Glover, D M | [[Category: Glover, D M]] | ||
[[Category: Grabarek, J | [[Category: Grabarek, J]] | ||
[[Category: Griffiths, G | [[Category: Griffiths, G]] | ||
[[Category: Ingram, L | [[Category: Ingram, L]] | ||
[[Category: Jackson, R C | [[Category: Jackson, R C]] | ||
[[Category: Jackson, W | [[Category: Jackson, W]] | ||
[[Category: Kontopidis, G | [[Category: Kontopidis, G]] | ||
[[Category: Lane, D P | [[Category: Lane, D P]] | ||
[[Category: Mcclue, S J | [[Category: Mcclue, S J]] | ||
[[Category: Mcinnes, C | [[Category: Mcinnes, C]] | ||
[[Category: Mclachlan, J | [[Category: Mclachlan, J]] | ||
[[Category: Meades, C | [[Category: Meades, C]] | ||
[[Category: Mezna, M | [[Category: Mezna, M]] | ||
[[Category: Midgley, C A | [[Category: Midgley, C A]] | ||
[[Category: Stuart, I | [[Category: Stuart, I]] | ||
[[Category: Thomas, M P | [[Category: Thomas, M P]] | ||
[[Category: Wang, S | [[Category: Wang, S]] | ||
[[Category: Zheleva, D I | [[Category: Zheleva, D I]] | ||
[[Category: Cdk9 inhibitor]] | [[Category: Cdk9 inhibitor]] | ||
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||