2gnk: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2gnk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GNK FirstGlance]. <br> | <table><tr><td colspan='2'>[[2gnk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GNK FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gnk RCSB], [http://www.ebi.ac.uk/pdbsum/2gnk PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gnk RCSB], [http://www.ebi.ac.uk/pdbsum/2gnk PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/GLNK_ECOLI GLNK_ECOLI]] P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Carr, P D | [[Category: Carr, P D]] | ||
[[Category: Cheah, E | [[Category: Cheah, E]] | ||
[[Category: Heeswijk, W C.van | [[Category: Heeswijk, W C.van]] | ||
[[Category: Ollis, D L | [[Category: Ollis, D L]] | ||
[[Category: Vasudevan, S G | [[Category: Vasudevan, S G]] | ||
[[Category: Westerhoff, H V | [[Category: Westerhoff, H V]] | ||
[[Category: Xu, Y | [[Category: Xu, Y]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||