2xct: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xct]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XCT FirstGlance]. <br> | <table><tr><td colspan='2'>[[2xct]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XCT FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPF:1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>CPF</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPF:1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>CPF</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xcs|2xcs]], [[2xco|2xco]], [[2xcq|2xcq]], [[2xcr|2xcr]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xcs|2xcs]], [[2xco|2xco]], [[2xcq|2xcq]], [[2xcr|2xcr]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xct OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xct RCSB], [http://www.ebi.ac.uk/pdbsum/2xct PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xct OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xct RCSB], [http://www.ebi.ac.uk/pdbsum/2xct PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
[[Category: Bax, B D | [[Category: Bax, B D]] | ||
[[Category: Brown, K K | [[Category: Brown, K K]] | ||
[[Category: Chan, P | [[Category: Chan, P]] | ||
[[Category: Eggleston, D S | [[Category: Eggleston, D S]] | ||
[[Category: Fosberry, A | [[Category: Fosberry, A]] | ||
[[Category: Gentry, D R | [[Category: Gentry, D R]] | ||
[[Category: Giordano, I | [[Category: Giordano, I]] | ||
[[Category: Gorrec, F | [[Category: Gorrec, F]] | ||
[[Category: Gwynn, M N | [[Category: Gwynn, M N]] | ||
[[Category: Hann, M M | [[Category: Hann, M M]] | ||
[[Category: Hennessy, A | [[Category: Hennessy, A]] | ||
[[Category: Hibbs, M | [[Category: Hibbs, M]] | ||
[[Category: Huang, J | [[Category: Huang, J]] | ||
[[Category: Jones, E | [[Category: Jones, E]] | ||
[[Category: Jones, J | [[Category: Jones, J]] | ||
[[Category: Lewis, C J | [[Category: Lewis, C J]] | ||
[[Category: May, E | [[Category: May, E]] | ||
[[Category: Pearson, N D | [[Category: Pearson, N D]] | ||
[[Category: Shen, C | [[Category: Shen, C]] | ||
[[Category: Shillings, A | [[Category: Shillings, A]] | ||
[[Category: Singh, O | [[Category: Singh, O]] | ||
[[Category: Spitzfaden, C | [[Category: Spitzfaden, C]] | ||
[[Category: Theobald, A | [[Category: Theobald, A]] | ||
[[Category: Wohlkonig, A | [[Category: Wohlkonig, A]] | ||
[[Category: Isomerase-dna-antibiotic complex]] | [[Category: Isomerase-dna-antibiotic complex]] | ||