2agt: Difference between revisions

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-[[Image:2agt.gif|left|200px]]<br /><applet load="2agt" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2agt.gif|left|200px]]
-caption="2agt, resolution 1.00&Aring;" />
-'''Aldose Reductase Mutant Leu 300 Pro complexed with Fidarestat'''<br />
+ {{Structure
+|PDB= 2agt |SIZE=350|CAPTION= <scene name='initialview01'>2agt</scene>, resolution 1.00&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=FID:(2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE'>FID</scene> and <scene name='pdbligand=CIT:CITRIC ACID'>CIT</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21]
+|GENE= AKR1B1, ALDR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''Aldose Reductase Mutant Leu 300 Pro complexed with Fidarestat'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-AGT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=NAP:'>NAP</scene>, <scene name='pdbligand=FID:'>FID</scene> and <scene name='pdbligand=CIT:'>CIT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AGT OCA].
+AGT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AGT OCA].
 ==Reference==
-Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex., Petrova T, Steuber H, Hazemann I, Cousido-Siah A, Mitschler A, Chung R, Oka M, Klebe G, El-Kabbani O, Joachimiak A, Podjarny A, J Med Chem. 2005 Sep 8;48(18):5659-65. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16134934 16134934]
+Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex., Petrova T, Steuber H, Hazemann I, Cousido-Siah A, Mitschler A, Chung R, Oka M, Klebe G, El-Kabbani O, Joachimiak A, Podjarny A, J Med Chem. 2005 Sep 8;48(18):5659-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16134934 16134934]
 [[Category: Aldehyde reductase]]
 [[Category: Homo sapiens]]
@@ Line 33: / Line 42: @@
 [[Category: oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:27:16 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:49:32 2008''