4cbx: Difference between revisions
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<StructureSection load='4cbx' size='340' side='right' caption='[[4cbx]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='4cbx' size='340' side='right' caption='[[4cbx]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cbx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBX OCA]. <br> | <table><tr><td colspan='2'>[[4cbx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Plabe Plabe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CBX FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cbu|4cbu]], [[4cbw|4cbw]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cbu|4cbu]], [[4cbw|4cbw]]</td></tr> | ||
<tr | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cbx RCSB], [http://www.ebi.ac.uk/pdbsum/4cbx PDBsum]</span></td></tr> | ||
</table> | |||
<table> | == Function == | ||
[[http://www.uniprot.org/uniprot/ACT2_PLABA ACT2_PLABA]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [[http://www.uniprot.org/uniprot/GELS_MOUSE GELS_MOUSE]] Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Structural differences explain diverse functions of Plasmodium actins.,Vahokoski J, Bhargav SP, Desfosses A, Andreadaki M, Kumpula EP, Martinez SM, Ignatev A, Lepper S, Frischknecht F, Siden-Kiamos I, Sachse C, Kursula I PLoS Pathog. 2014 Apr 17;10(4):e1004091. doi: 10.1371/journal.ppat.1004091., eCollection 2014 Apr. PMID:24743229<ref>PMID:24743229</ref> | Structural differences explain diverse functions of Plasmodium actins.,Vahokoski J, Bhargav SP, Desfosses A, Andreadaki M, Kumpula EP, Martinez SM, Ignatev A, Lepper S, Frischknecht F, Siden-Kiamos I, Sachse C, Kursula I PLoS Pathog. 2014 Apr 17;10(4):e1004091. doi: 10.1371/journal.ppat.1004091., eCollection 2014 Apr. PMID:24743229<ref>PMID:24743229</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Andreadaki, M | [[Category: Lk3 transgenic mice]] | ||
[[Category: Bhargav, S P | [[Category: Plabe]] | ||
[[Category: Desfosses, A | [[Category: Andreadaki, M]] | ||
[[Category: Frischknecht, F | [[Category: Bhargav, S P]] | ||
[[Category: Ignatev, A | [[Category: Desfosses, A]] | ||
[[Category: Kumpula, E P | [[Category: Frischknecht, F]] | ||
[[Category: Kursula, I | [[Category: Ignatev, A]] | ||
[[Category: Lepper, S | [[Category: Kumpula, E P]] | ||
[[Category: Martinez, S Munico | [[Category: Kursula, I]] | ||
[[Category: Sachse, C | [[Category: Lepper, S]] | ||
[[Category: Siden-Kiamos, I | [[Category: Martinez, S Munico]] | ||
[[Category: Vahokoski, J | [[Category: Sachse, C]] | ||
[[Category: Siden-Kiamos, I]] | |||
[[Category: Vahokoski, J]] | |||
[[Category: Malaria]] | [[Category: Malaria]] | ||
[[Category: Motility]] | [[Category: Motility]] | ||
[[Category: Motor protein]] | [[Category: Motor protein]] | ||
[[Category: Parasite]] | [[Category: Parasite]] | ||