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{{STRUCTURE_4j6g| PDB=4j6g | SCENE= }}
==CRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEX==
===CRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEX===
<StructureSection load='4j6g' size='340' side='right' caption='[[4j6g]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4j6g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J6G FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4en0|4en0]], [[3k51|3k51]], [[3mi8|3mi8]], [[3mhd|3mhd]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFSF14, HVEML, LIGHT, UNQ391/PRO726 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), TNFRSF6B, DCR3, TR6, UNQ186/PRO212 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j6g RCSB], [http://www.ebi.ac.uk/pdbsum/4j6g PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. [[http://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN]] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref>   
[[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. [[http://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN]] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref>   


==About this Structure==
==See Also==
[[4j6g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J6G OCA].
*[[Tumor necrosis factor receptor|Tumor necrosis factor receptor]]
 
== References ==
==Reference==
<references/>
<references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Almo, S C.]]
[[Category: Almo, S C]]
[[Category: Bhosle, R C.]]
[[Category: Bhosle, R C]]
[[Category: Bonanno, J B.]]
[[Category: Bonanno, J B]]
[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]
[[Category: IFN, Atoms-to-Animals:.The Immune Function Network]]
[[Category: Liu, W.]]
[[Category: Liu, W]]
[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
[[Category: Structural genomic]]
[[Category: Nathenson, S G.]]
[[Category: Nathenson, S G]]
[[Category: Zhan, C.]]
[[Category: Zhan, C]]
[[Category: Atoms-to-animals: the immune function network]]
[[Category: Atoms-to-animals: the immune function network]]
[[Category: Bind tnf receptor hvem and ltbr]]
[[Category: Bind tnf receptor hvem and ltbr]]
Line 31: Line 38:
[[Category: N-glycosylation]]
[[Category: N-glycosylation]]
[[Category: New hvem]]
[[Category: New hvem]]
[[Category: New york structural genomics research consortium]]
[[Category: Nysgrc]]
[[Category: Nysgrc]]
[[Category: Protein structure initiative]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Psi-biology]]
[[Category: Secreted protein]]
[[Category: Secreted protein]]
[[Category: Structural genomic]]
[[Category: Tnf]]
[[Category: Tnf]]
[[Category: Tnf14]]
[[Category: Tnf14]]
[[Category: Tnfr]]
[[Category: Tnfr]]

Revision as of 03:10, 25 December 2014

CRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEXCRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEX

Structural highlights

4j6g is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , ,
Gene:TNFSF14, HVEML, LIGHT, UNQ391/PRO726 (Homo sapiens), TNFRSF6B, DCR3, TR6, UNQ186/PRO212 (Homo sapiens)
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[TNF14_HUMAN] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. [TNF6B_HUMAN] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.[1]

See Also

References

  1. ↑ Zhan C, Patskovsky Y, Yan Q, Li Z, Ramagopal U, Cheng H, Brenowitz M, Hui X, Nathenson SG, Almo SC. Decoy Strategies: The Structure of TL1A:DcR3 Complex. Structure. 2011 Feb 9;19(2):162-71. PMID:21300286 doi:10.1016/j.str.2010.12.004

4j6g, resolution 2.40Å

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