4b12: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b12 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b12 RCSB], [http://www.ebi.ac.uk/pdbsum/4b12 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b12 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b12 RCSB], [http://www.ebi.ac.uk/pdbsum/4b12 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/A5K1A2_PLAVS A5K1A2_PLAVS]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586] | |||
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== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 02:55, 25 December 2014
Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 23)Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 23)
Structural highlights
Function[A5K1A2_PLAVS] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586] Publication Abstract from PubMedDesign of inhibitors for N-myristoyltransferase (NMT), an enzyme responsible for protein trafficking in Plasmodium falciparum , the most lethal species of parasites that cause malaria, is described. Chemistry-driven optimization of compound 1 from a focused NMT inhibitor library led to the identification of two early lead compounds 4 and 25, which showed good enzyme and cellular potency and excellent selectivity over human NMT. These molecules provide a valuable starting point for further development. Design and Synthesis of Inhibitors of Plasmodium falciparum N-Myristoyltransferase, A Promising Target for Antimalarial Drug Discovery.,Yu Z, Brannigan JA, Moss DK, Brzozowski AM, Wilkinson AJ, Holder AA, Tate EW, Leatherbarrow RJ J Med Chem. 2012 Oct 15. PMID:23035716[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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