2aaq: Difference between revisions
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[[Image:2aaq.gif|left|200px]] | [[Image:2aaq.gif|left|200px]] | ||
'''Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI''' | {{Structure | ||
|PDB= 2aaq |SIZE=350|CAPTION= <scene name='initialview01'>2aaq</scene>, resolution 2.60Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=AUP:2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINE'>AUP</scene>, <scene name='pdbligand=AU:GOLD+ION'>AU</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Glutathione-disulfide_reductase Glutathione-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.7 1.8.1.7] | |||
|GENE= hGR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI''' | |||
==Disease== | ==Disease== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
2AAQ is a [ | 2AAQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AAQ OCA]. | ||
==Reference== | ==Reference== | ||
Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases., Urig S, Fritz-Wolf K, Reau R, Herold-Mende C, Toth K, Davioud-Charvet E, Becker K, Angew Chem Int Ed Engl. 2006 Mar 13;45(12):1881-6. PMID:[http:// | Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases., Urig S, Fritz-Wolf K, Reau R, Herold-Mende C, Toth K, Davioud-Charvet E, Becker K, Angew Chem Int Ed Engl. 2006 Mar 13;45(12):1881-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16493712 16493712] | ||
[[Category: Glutathione-disulfide reductase]] | [[Category: Glutathione-disulfide reductase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| Line 35: | Line 44: | ||
[[Category: protein gold complex]] | [[Category: protein gold complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:47:30 2008'' | ||
Revision as of 16:47, 20 March 2008
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| , resolution 2.60Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , , and | ||||||
| Gene: | hGR (Homo sapiens) | ||||||
| Activity: | Glutathione-disulfide reductase, with EC number 1.8.1.7 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI
DiseaseDisease
Known diseases associated with this structure: Hemolytic anemia due to glutathione reductase deficiency OMIM:[138300], Mental retardation, autosomal recessive, 6 OMIM:[138244]
About this StructureAbout this Structure
2AAQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases., Urig S, Fritz-Wolf K, Reau R, Herold-Mende C, Toth K, Davioud-Charvet E, Becker K, Angew Chem Int Ed Engl. 2006 Mar 13;45(12):1881-6. PMID:16493712
Page seeded by OCA on Thu Mar 20 15:47:30 2008