3av5: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3av5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3av5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3av5 RCSB], [http://www.ebi.ac.uk/pdbsum/3av5 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3av5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3av5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3av5 RCSB], [http://www.ebi.ac.uk/pdbsum/3av5 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/DNMT1_MOUSE DNMT1_MOUSE]] Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.<ref>PMID:11290321</ref> <ref>PMID:15550930</ref> <ref>PMID:17576694</ref> | |||
==See Also== | ==See Also== | ||
*[[DNA methyltransferase|DNA methyltransferase]] | *[[DNA methyltransferase|DNA methyltransferase]] | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Nakagawa, A | [[Category: Nakagawa, A]] | ||
[[Category: Narita, H | [[Category: Narita, H]] | ||
[[Category: Suetake, I | [[Category: Suetake, I]] | ||
[[Category: Suga, M | [[Category: Suga, M]] | ||
[[Category: Tajima, S | [[Category: Tajima, S]] | ||
[[Category: Takeshita, K | [[Category: Takeshita, K]] | ||
[[Category: Yamashita, E | [[Category: Yamashita, E]] | ||
[[Category: Cxxc-type zinc finger/c5-methyltransferase family]] | [[Category: Cxxc-type zinc finger/c5-methyltransferase family]] | ||
[[Category: Dna binding]] | [[Category: Dna binding]] | ||
Revision as of 02:36, 25 December 2014
Crystal structure of mouse DNA methyltransferase 1 with AdoHcyCrystal structure of mouse DNA methyltransferase 1 with AdoHcy
Structural highlights
Function[DNMT1_MOUSE] Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.[1] [2] [3] See AlsoReferences
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