2a4e: Difference between revisions

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Revision as of 16:45, 20 March 2008

File:2a4e.gif

, resolution 3.200Å

Ligands:

Gene:

Cdh11, Cad-11 (Mus musculus)

Coordinates:

save as pdb, mmCIF, xml

Crystal structure of mouse cadherin-11 EC1-2

OverviewOverview

Type I and II classical cadherins help to determine the adhesive specificities of animal cells. Crystal-structure determination of ectodomain regions from three type II cadherins reveals adhesive dimers formed by exchange of N-terminal beta strands between partner extracellular cadherin-1 (EC1) domains. These interfaces have two conserved tryptophan side chains that anchor each swapped strand, compared with one in type I cadherins, and include large hydrophobic regions unique to type II interfaces. The EC1 domains of type I and type II cadherins appear to encode cell adhesive specificity in vitro. Moreover, perturbation of motor neuron segregation with chimeric cadherins depends on EC1 domain identity, suggesting that this region, which includes the structurally defined adhesive interface, encodes type II cadherin functional specificity in vivo.

About this StructureAbout this Structure

2A4E is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Type II cadherin ectodomain structures: implications for classical cadherin specificity., Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L, Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015

Page seeded by OCA on Thu Mar 20 15:45:14 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2a4e.gif|left|200px]]<br /><applet load="2a4e" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2a4e.gif|left|200px]]
-caption="2a4e, resolution 3.200&Aring;" />
-'''Crystal structure of mouse cadherin-11 EC1-2'''<br />
+ {{Structure
+|PDB= 2a4e |SIZE=350|CAPTION= <scene name='initialview01'>2a4e</scene>, resolution 3.200&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
+|ACTIVITY=
+|GENE= Cdh11, Cad-11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+}}
+'''Crystal structure of mouse cadherin-11 EC1-2'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-A4E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4E OCA].
+A4E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4E OCA].
 ==Reference==
-Type II cadherin ectodomain structures: implications for classical cadherin specificity., Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L, Cell. 2006 Mar 24;124(6):1255-68. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16564015 16564015]
+Type II cadherin ectodomain structures: implications for classical cadherin specificity., Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L, Cell. 2006 Mar 24;124(6):1255-68. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16564015 16564015]
 [[Category: Mus musculus]]
 [[Category: Single protein]]
@@ Line 28: / Line 37: @@
 [[Category: dimer]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:23:30 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:45:14 2008''