1k0m: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1k0m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K0M FirstGlance]. <br> | <table><tr><td colspan='2'>[[1k0m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K0M FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k0m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k0m RCSB], [http://www.ebi.ac.uk/pdbsum/1k0m PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k0m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k0m RCSB], [http://www.ebi.ac.uk/pdbsum/1k0m PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN]] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bauskin, A R | [[Category: Bauskin, A R]] | ||
[[Category: Breit, S N | [[Category: Breit, S N]] | ||
[[Category: Campbell, T J | [[Category: Campbell, T J]] | ||
[[Category: Curmi, P M.G | [[Category: Curmi, P M.G]] | ||
[[Category: DeMaere, M Z | [[Category: DeMaere, M Z]] | ||
[[Category: Fairlie, W D | [[Category: Fairlie, W D]] | ||
[[Category: Harrop, S J | [[Category: Harrop, S J]] | ||
[[Category: Jankova, L | [[Category: Jankova, L]] | ||
[[Category: Mazzanti, M | [[Category: Mazzanti, M]] | ||
[[Category: Pankhurst, S | [[Category: Pankhurst, S]] | ||
[[Category: Qiu, M R | [[Category: Qiu, M R]] | ||
[[Category: Reztsova, T | [[Category: Reztsova, T]] | ||
[[Category: Tonini, R | [[Category: Tonini, R]] | ||
[[Category: Valenzuela, S M | [[Category: Valenzuela, S M]] | ||
[[Category: Warton, K | [[Category: Warton, K]] | ||
[[Category: Wu, W M | [[Category: Wu, W M]] | ||
[[Category: Chloride ion channel]] | [[Category: Chloride ion channel]] | ||
[[Category: Glutathione-s-tranferase superfamily]] | [[Category: Glutathione-s-tranferase superfamily]] | ||
[[Category: Metal transport]] | [[Category: Metal transport]] | ||
Revision as of 01:56, 25 December 2014
Crystal structure of a soluble monomeric form of CLIC1 at 1.4 angstromsCrystal structure of a soluble monomeric form of CLIC1 at 1.4 angstroms
Structural highlights
Function[CLIC1_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.[1] [2] [3] [4] [5] [6] [7] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedCLIC1 (NCC27) is a member of the highly conserved class of chloride ion channels that exists in both soluble and integral membrane forms. Purified CLIC1 can integrate into synthetic lipid bilayers forming a chloride channel with similar properties to those observed in vivo. The structure of the soluble form of CLIC1 has been determined at 1.4-A resolution. The protein is monomeric and structurally homologous to the glutathione S-transferase superfamily, and it has a redox-active site resembling glutaredoxin. The structure of the complex of CLIC1 with glutathione shows that glutathione occupies the redox-active site, which is adjacent to an open, elongated slot lined by basic residues. Integration of CLIC1 into the membrane is likely to require a major structural rearrangement, probably of the N-domain (residues 1-90), with the putative transmembrane helix arising from residues in the vicinity of the redox-active site. The structure indicates that CLIC1 is likely to be controlled by redox-dependent processes. Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.,Harrop SJ, DeMaere MZ, Fairlie WD, Reztsova T, Valenzuela SM, Mazzanti M, Tonini R, Qiu MR, Jankova L, Warton K, Bauskin AR, Wu WM, Pankhurst S, Campbell TJ, Breit SN, Curmi PM J Biol Chem. 2001 Nov 30;276(48):44993-5000. Epub 2001 Sep 10. PMID:11551966[8] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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