2mbc: Difference between revisions

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{{STRUCTURE_2mbc|  PDB=2mbc  |  SCENE=  }}
==Solution Structure of human holo-PRL-3 in complex with vanadate==
===Solution Structure of human holo-PRL-3 in complex with vanadate===
<StructureSection load='2mbc' size='340' side='right' caption='[[2mbc]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[2mbc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MBC FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1v3a|1v3a]], [[1r6h|1r6h]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTP4A3, PRL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mbc RCSB], [http://www.ebi.ac.uk/pdbsum/2mbc PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TP4A3_HUMAN TP4A3_HUMAN]] Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.<ref>PMID:11355880</ref> <ref>PMID:12782572</ref>   
[[http://www.uniprot.org/uniprot/TP4A3_HUMAN TP4A3_HUMAN]] Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.<ref>PMID:11355880</ref> <ref>PMID:12782572</ref>   


==About this Structure==
==See Also==
[[2mbc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBC OCA].
*[[Dual specificity phosphatase|Dual specificity phosphatase]]
 
*[[Tyrosine phosphatase|Tyrosine phosphatase]]
==Reference==
== References ==
<references group="xtra"/><references/>
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Jeon, Y H.]]
[[Category: Jeon, Y H]]
[[Category: Jeong, K.]]
[[Category: Jeong, K]]
[[Category: Jin, B.]]
[[Category: Jin, B]]
[[Category: Kang, D.]]
[[Category: Kang, D]]
[[Category: Kim, E.]]
[[Category: Kim, E]]
[[Category: Kim, J.]]
[[Category: Kim, J]]
[[Category: Kim, Y.]]
[[Category: Kim, Y]]
[[Category: Lee, C.]]
[[Category: Lee, C]]
[[Category: Shin, S.]]
[[Category: Shin, S]]
[[Category: Holo-prl-3]]
[[Category: Holo-prl-3]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Vanadate]]
[[Category: Vanadate]]

Revision as of 01:13, 25 December 2014

Solution Structure of human holo-PRL-3 in complex with vanadateSolution Structure of human holo-PRL-3 in complex with vanadate

Structural highlights

2mbc is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:PTP4A3, PRL3 (Homo sapiens)
Activity:Protein-tyrosine-phosphatase, with EC number 3.1.3.48
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[TP4A3_HUMAN] Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.[1] [2]

See Also

References

  1. ↑ Matter WF, Estridge T, Zhang C, Belagaje R, Stancato L, Dixon J, Johnson B, Bloem L, Pickard T, Donaghue M, Acton S, Jeyaseelan R, Kadambi V, Vlahos CJ. Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling. Biochem Biophys Res Commun. 2001 May 25;283(5):1061-8. PMID:11355880 doi:http://dx.doi.org/10.1006/bbrc.2001.4881
  2. ↑ Zeng Q, Dong JM, Guo K, Li J, Tan HX, Koh V, Pallen CJ, Manser E, Hong W. PRL-3 and PRL-1 promote cell migration, invasion, and metastasis. Cancer Res. 2003 Jun 1;63(11):2716-22. PMID:12782572
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