1zrt: Difference between revisions

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Revision as of 16:39, 20 March 2008

File:1zrt.gif

, resolution 3.50Å

Ligands:

, , and

Activity:

Ubiquinol--cytochrome-c reductase, with EC number 1.10.2.2

Coordinates:

save as pdb, mmCIF, xml

Rhodobacter capsulatus cytochrome bc1 complex with stigmatellin bound

OverviewOverview

Ubihydroquinone: cytochrome (cyt)c oxidoreductase, or cyt bc (1), is a widespread, membrane integral enzyme that plays a crucial role during photosynthesis and respiration. It is one of the major contributors of the electrochemical proton gradient, which is subsequently used for ATP synthesis. The simplest form of the cyt bc (1) is found in bacteria, and it contains only the three ubiquitously conserved catalytic subunits: the Fe-S protein, cyt b and cyt c (1). Here we present a preliminary X-ray structure of Rhodobacter capsulatus cyt bc (1) at 3.8 A and compare it to the available structures of its homologues from mitochondria and chloroplast. Using the bacterial enzyme structure, we highlight the structural similarities and differences that are found among the three catalytic subunits between the members of this family of enzymes. In addition, we discuss the locations of currently known critical mutations, and their implications in terms of the cyt bc (1) catalysis.

About this StructureAbout this Structure

1ZRT is a Protein complex structure of sequences from Rhodobacter capsulatus. Full crystallographic information is available from OCA.

ReferenceReference

X-Ray Structure of Rhodobacter Capsulatus Cytochrome bc (1): Comparison with its Mitochondrial and Chloroplast Counterparts., Berry EA, Huang LS, Saechao LK, Pon NG, Valkova-Valchanova M, Daldal F, Photosynth Res. 2004;81(3):251-75. PMID:16034531

Page seeded by OCA on Thu Mar 20 15:39:06 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1zrt.gif|left|200px]]<br /><applet load="1zrt" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1zrt.gif|left|200px]]
-caption="1zrt, resolution 3.50&Aring;" />
-'''Rhodobacter capsulatus cytochrome bc1 complex with stigmatellin bound'''<br />
+ {{Structure
+|PDB= 1zrt |SIZE=350|CAPTION= <scene name='initialview01'>1zrt</scene>, resolution 3.50&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SMA:STIGMATELLIN+A'>SMA</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene> and <scene name='pdbligand=FES:FE2/S2 (INORGANIC) CLUSTER'>FES</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Ubiquinol--cytochrome-c_reductase Ubiquinol--cytochrome-c reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.2.2 1.10.2.2]
+|GENE=
+}}
+'''Rhodobacter capsulatus cytochrome bc1 complex with stigmatellin bound'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-ZRT is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rhodobacter_capsulatus Rhodobacter capsulatus] with <scene name='pdbligand=HEM:'>HEM</scene>, <scene name='pdbligand=SMA:'>SMA</scene>, <scene name='pdbligand=HEC:'>HEC</scene> and <scene name='pdbligand=FES:'>FES</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Ubiquinol--cytochrome-c_reductase Ubiquinol--cytochrome-c reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.2.2 1.10.2.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZRT OCA].
+ZRT is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rhodobacter_capsulatus Rhodobacter capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZRT OCA].
 ==Reference==
-X-Ray Structure of Rhodobacter Capsulatus Cytochrome bc (1): Comparison with its Mitochondrial and Chloroplast Counterparts., Berry EA, Huang LS, Saechao LK, Pon NG, Valkova-Valchanova M, Daldal F, Photosynth Res. 2004;81(3):251-75. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16034531 16034531]
+X-Ray Structure of Rhodobacter Capsulatus Cytochrome bc (1): Comparison with its Mitochondrial and Chloroplast Counterparts., Berry EA, Huang LS, Saechao LK, Pon NG, Valkova-Valchanova M, Daldal F, Photosynth Res. 2004;81(3):251-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16034531 16034531]
 [[Category: Protein complex]]
 [[Category: Rhodobacter capsulatus]]
@@ Line 36: / Line 45: @@
 [[Category: stigmatellin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:18:27 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:39:06 2008''