1zro: Difference between revisions
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[[Image:1zro.gif|left|200px]] | [[Image:1zro.gif|left|200px]] | ||
'''Crystal structure of EBA-175 Region II (RII) crystallized in the presence of (alpha)2,3-sialyllactose''' | {{Structure | ||
|PDB= 1zro |SIZE=350|CAPTION= <scene name='initialview01'>1zro</scene>, resolution 2.25Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''Crystal structure of EBA-175 Region II (RII) crystallized in the presence of (alpha)2,3-sialyllactose''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1ZRO is a [ | 1ZRO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZRO OCA]. | ||
==Reference== | ==Reference== | ||
Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum., Tolia NH, Enemark EJ, Sim BK, Joshua-Tor L, Cell. 2005 Jul 29;122(2):183-93. PMID:[http:// | Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum., Tolia NH, Enemark EJ, Sim BK, Joshua-Tor L, Cell. 2005 Jul 29;122(2):183-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16051144 16051144] | ||
[[Category: Plasmodium falciparum]] | [[Category: Plasmodium falciparum]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: sialyllactose]] | [[Category: sialyllactose]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:39:01 2008'' | ||
Revision as of 16:39, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of EBA-175 Region II (RII) crystallized in the presence of (alpha)2,3-sialyllactose
OverviewOverview
Erythrocyte binding antigen 175 (EBA-175) is a P. falciparum protein that binds the major glycoprotein found on human erythrocytes, glycophorin A, during invasion. Here we present the crystal structure of the erythrocyte binding domain of EBA-175, RII, which has been established as a vaccine candidate. Binding sites for the heavily sialylated receptor glycophorin A are proposed based on a complex of RII with a glycan that contains the essential components required for binding. The dimeric organization of RII displays two prominent channels that contain four of the six observed glycan binding sites. Each monomer consists of two Duffy binding-like (DBL) domains (F1 and F2). F2 more prominently lines the channels and makes the majority of the glycan contacts, underscoring its role in cytoadherence and in antigenic variation in malaria. Our studies provide insight into the mechanism of erythrocyte invasion by the malaria parasite and aid in rational drug design and vaccines.
About this StructureAbout this Structure
1ZRO is a Single protein structure of sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.
ReferenceReference
Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum., Tolia NH, Enemark EJ, Sim BK, Joshua-Tor L, Cell. 2005 Jul 29;122(2):183-93. PMID:16051144
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