4om5: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4om5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OM5 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4om5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OM5 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4om4|4om4]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4om4|4om4]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4om5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4om5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4om5 RCSB], [http://www.ebi.ac.uk/pdbsum/4om5 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4om5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4om5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4om5 RCSB], [http://www.ebi.ac.uk/pdbsum/4om5 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CTXA4_NAJAT CTXA4_NAJAT]] Basic protein that bind to cell membrane and depolarizes cardiomyocytes. This cytotoxin also shows lytic activities, but 2-fold more important than that of CTX-A2. It binds to the integrin alpha-V/beta-3 with a moderate affinity. Inhibits protein kinase C. It may interact with sulfatides in the cell membrane, which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induces mitochondrial swelling and fragmentation.<ref>PMID:8448165</ref> <ref>PMID:16407244</ref> <ref>PMID:9398182</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Naja atra]] | [[Category: Naja atra]] | ||
[[Category: Chang, C I | [[Category: Chang, C I]] | ||
[[Category: Lin, C C | [[Category: Lin, C C]] | ||
[[Category: Wu, W G | [[Category: Wu, W G]] | ||
[[Category: Endocytosis]] | [[Category: Endocytosis]] | ||
[[Category: Five beta sheet]] | [[Category: Five beta sheet]] | ||