1zr5: Difference between revisions

Revision as of 16:38, 20 March 2008

, resolution 2.92Å

Coordinates:

Crystal structure of the macro-domain of human core histone variant macroH2A1.2

OverviewOverview

Histone macroH2A is a hallmark of mammalian heterochromatin. Here we show that human macroH2A1.1 binds the SirT1-metabolite O-acetyl-ADP-ribose (OAADPR) through its macro domain. The 1.6-A crystal structure and mutants reveal how the metabolite is recognized. Mutually exclusive exon use in the gene H2AFY produces macroH2A1.2, whose tissue distribution differs. MacroH2A1.2 shows only subtle structural changes but cannot bind nucleotides. Alternative splicing may thus regulate the binding of nicotinamide adenine dinucleotide (NAD) metabolites to chromatin.

About this StructureAbout this Structure

1ZR5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Splicing regulates NAD metabolite binding to histone macroH2A., Kustatscher G, Hothorn M, Pugieux C, Scheffzek K, Ladurner AG, Nat Struct Mol Biol. 2005 Jul;12(7):624-5. Epub 2005 Jun 19. PMID:15965484

Page seeded by OCA on Thu Mar 20 15:38:52 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1zr5.gif|left|200px]]<br /><applet load="1zr5" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1zr5.gif|left|200px]]
-caption="1zr5, resolution 2.92&Aring;" />
-'''Crystal structure of the macro-domain of human core histone variant macroH2A1.2'''<br />
+ {{Structure
+|PDB= 1zr5 |SIZE=350|CAPTION= <scene name='initialview01'>1zr5</scene>, resolution 2.92&Aring;
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE=
+}}
+'''Crystal structure of the macro-domain of human core histone variant macroH2A1.2'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-ZR5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZR5 OCA].
+ZR5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZR5 OCA].
 ==Reference==
-Splicing regulates NAD metabolite binding to histone macroH2A., Kustatscher G, Hothorn M, Pugieux C, Scheffzek K, Ladurner AG, Nat Struct Mol Biol. 2005 Jul;12(7):624-5. Epub 2005 Jun 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15965484 15965484]
+Splicing regulates NAD metabolite binding to histone macroH2A., Kustatscher G, Hothorn M, Pugieux C, Scheffzek K, Ladurner AG, Nat Struct Mol Biol. 2005 Jul;12(7):624-5. Epub 2005 Jun 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15965484 15965484]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
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 [[Category: splicing]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:18:16 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:38:52 2008''