2dx0: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2dx0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DX0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2dx0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DX0 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dx0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dx0 RCSB], [http://www.ebi.ac.uk/pdbsum/2dx0 PDBsum], [http://www.topsan.org/Proteins/RSGI/2dx0 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dx0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dx0 RCSB], [http://www.ebi.ac.uk/pdbsum/2dx0 PDBsum], [http://www.topsan.org/Proteins/RSGI/2dx0 TOPSAN]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PLCG2_MOUSE PLCG2_MOUSE]] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Handa, N | [[Category: Handa, N]] | ||
[[Category: Murayama, K | [[Category: Murayama, K]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Shirouzu, M | [[Category: Shirouzu, M]] | ||
[[Category: Takagi, T | [[Category: Takagi, T]] | ||
[[Category: Terada, T | [[Category: Terada, T]] | ||
[[Category: Yokoyama, S | [[Category: Yokoyama, S]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: National project on protein structural and functional analyse]] | [[Category: National project on protein structural and functional analyse]] | ||
[[Category: Nppsfa]] | [[Category: Nppsfa]] | ||
[[Category: Phosphoric diester hydrolase]] | [[Category: Phosphoric diester hydrolase]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
Revision as of 23:52, 24 December 2014
Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2
Structural highlights
Function[PLCG2_MOUSE] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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