1zjr: Difference between revisions
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[[Image:1zjr.gif|left|200px]] | [[Image:1zjr.gif|left|200px]] | ||
'''Crystal Structure of A. aeolicus TrmH/SpoU tRNA modifying enzyme''' | {{Structure | ||
|PDB= 1zjr |SIZE=350|CAPTION= <scene name='initialview01'>1zjr</scene>, resolution 1.85Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/tRNA_guanosine-2'-O-methyltransferase tRNA guanosine-2'-O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.34 2.1.1.34] | |||
|GENE= trmH, spoU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 Aquifex aeolicus]) | |||
}} | |||
'''Crystal Structure of A. aeolicus TrmH/SpoU tRNA modifying enzyme''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1ZJR is a [ | 1ZJR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZJR OCA]. | ||
==Reference== | ==Reference== | ||
Structure of a class II TrmH tRNA-modifying enzyme from Aquifex aeolicus., Pleshe E, Truesdell J, Batey RT, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Aug 1;61(Pt, 8):722-8. Epub 2005 Jul 30. PMID:[http:// | Structure of a class II TrmH tRNA-modifying enzyme from Aquifex aeolicus., Pleshe E, Truesdell J, Batey RT, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Aug 1;61(Pt, 8):722-8. Epub 2005 Jul 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16511140 16511140] | ||
[[Category: Aquifex aeolicus]] | [[Category: Aquifex aeolicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: topological knot]] | [[Category: topological knot]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:36:24 2008'' | ||
Revision as of 16:36, 20 March 2008
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| , resolution 1.85Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Gene: | trmH, spoU (Aquifex aeolicus) | ||||||
| Activity: | tRNA guanosine-2'-O-methyltransferase, with EC number 2.1.1.34 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of A. aeolicus TrmH/SpoU tRNA modifying enzyme
OverviewOverview
Biological RNAs contain a variety of post-transcriptional modifications that facilitate their efficient function in the cellular environment. One of the two most common forms of modification is methylation of the 2'-hydroxyl group of the ribose sugar, which is performed by a number of S-adenosylmethionine (SAM) dependent methyltransferases. In bacteria, many of these modifications in tRNA and rRNA are carried out by the alpha/beta-knot superfamily of enzymes, whose SAM-binding pocket is created by a characteristic deep trefoil knot. TrmH, an enzyme found throughout all three kingdoms of life, modifies the universally conserved guanosine 18 position of tRNA. The crystal structure of TrmH from the thermophilic bacterium Aquifex aeolicus has been determined at 1.85 A resolution using data collected from a synchrotron-radiation source. The protein reveals a fold typical of members of the SpoU clan of proteins, a subfamily of the alpha/beta-knot superfamily, with alpha-helical extensions at the N- and C-termini that are likely to be involved in tRNA binding.
About this StructureAbout this Structure
1ZJR is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.
ReferenceReference
Structure of a class II TrmH tRNA-modifying enzyme from Aquifex aeolicus., Pleshe E, Truesdell J, Batey RT, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Aug 1;61(Pt, 8):722-8. Epub 2005 Jul 30. PMID:16511140
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