1zc8: Difference between revisions
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[[Image:1zc8.gif|left|200px]] | [[Image:1zc8.gif|left|200px]] | ||
'''Coordinates of tmRNA, SmpB, EF-Tu and h44 fitted into Cryo-EM map of the 70S ribosome and tmRNA complex''' | {{Structure | ||
|PDB= 1zc8 |SIZE=350|CAPTION= <scene name='initialview01'>1zc8</scene> | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''Coordinates of tmRNA, SmpB, EF-Tu and h44 fitted into Cryo-EM map of the 70S ribosome and tmRNA complex''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1ZC8 is a [ | 1ZC8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZC8 OCA]. | ||
==Reference== | ==Reference== | ||
Visualizing tmRNA entry into a stalled ribosome., Valle M, Gillet R, Kaur S, Henne A, Ramakrishnan V, Frank J, Science. 2003 Apr 4;300(5616):127-30. PMID:[http:// | Visualizing tmRNA entry into a stalled ribosome., Valle M, Gillet R, Kaur S, Henne A, Ramakrishnan V, Frank J, Science. 2003 Apr 4;300(5616):127-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12677067 12677067] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Thermus thermophilus]] | [[Category: Thermus thermophilus]] | ||
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[[Category: Valle, M.]] | [[Category: Valle, M.]] | ||
[[Category: 16s rrna]] | [[Category: 16s rrna]] | ||
[[Category: | [[Category: 30]] | ||
[[Category: | [[Category: 70]] | ||
[[Category: cryo-em]] | [[Category: cryo-em]] | ||
[[Category: ef-tu]] | [[Category: ef-tu]] | ||
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[[Category: trans-translation]] | [[Category: trans-translation]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:33:42 2008'' | ||
Revision as of 16:33, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Coordinates of tmRNA, SmpB, EF-Tu and h44 fitted into Cryo-EM map of the 70S ribosome and tmRNA complex
OverviewOverview
Bacterial ribosomes stalled on defective messenger RNAs (mRNAs) are rescued by tmRNA, an approximately 300-nucleotide-long molecule that functions as both transfer RNA (tRNA) and mRNA. Translation then switches from the defective message to a short open reading frame on tmRNA that tags the defective nascent peptide chain for degradation. However, the mechanism by which tmRNA can enter and move through the ribosome is unknown. We present a cryo-electron microscopy study at approximately 13 to 15 angstroms of the entry of tmRNA into the ribosome. The structure reveals how tmRNA could move through the ribosome despite its complicated topology and also suggests roles for proteins S1 and SmpB in the function of tmRNA.
About this StructureAbout this Structure
1ZC8 is a Protein complex structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.
ReferenceReference
Visualizing tmRNA entry into a stalled ribosome., Valle M, Gillet R, Kaur S, Henne A, Ramakrishnan V, Frank J, Science. 2003 Apr 4;300(5616):127-30. PMID:12677067
Page seeded by OCA on Thu Mar 20 15:33:42 2008