1zax: Difference between revisions
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[[Image:1zax.gif|left|200px]] | [[Image:1zax.gif|left|200px]] | ||
'''Ribosomal Protein L10-L12(NTD) Complex, Space Group P212121, Form B''' | {{Structure | ||
|PDB= 1zax |SIZE=350|CAPTION= <scene name='initialview01'>1zax</scene>, resolution 2.1Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= rplJ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima]), rplL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima]) | |||
}} | |||
'''Ribosomal Protein L10-L12(NTD) Complex, Space Group P212121, Form B''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1ZAX is a [ | 1ZAX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZAX OCA]. | ||
==Reference== | ==Reference== | ||
Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation., Diaconu M, Kothe U, Schlunzen F, Fischer N, Harms JM, Tonevitsky AG, Stark H, Rodnina MV, Wahl MC, Cell. 2005 Jul 1;121(7):991-1004. PMID:[http:// | Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation., Diaconu M, Kothe U, Schlunzen F, Fischer N, Harms JM, Tonevitsky AG, Stark H, Rodnina MV, Wahl MC, Cell. 2005 Jul 1;121(7):991-1004. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15989950 15989950] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Thermotoga maritima]] | [[Category: Thermotoga maritima]] | ||
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[[Category: l7/12 ribosomal stalk]] | [[Category: l7/12 ribosomal stalk]] | ||
[[Category: mechanism of translation]] | [[Category: mechanism of translation]] | ||
[[Category: rapid | [[Category: rapid kinetic]] | ||
[[Category: ribosome structure and function]] | [[Category: ribosome structure and function]] | ||
[[Category: thiostrepton loop of 23s rrna]] | [[Category: thiostrepton loop of 23s rrna]] | ||
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[[Category: x-ray crystallography]] | [[Category: x-ray crystallography]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:33:20 2008'' | ||
Revision as of 16:33, 20 March 2008
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| , resolution 2.1Å | |||||||
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| Gene: | rplJ (Thermotoga maritima), rplL (Thermotoga maritima) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Ribosomal Protein L10-L12(NTD) Complex, Space Group P212121, Form B
OverviewOverview
The L7/12 stalk of the large subunit of bacterial ribosomes encompasses protein L10 and multiple copies of L7/12. We present crystal structures of Thermotoga maritima L10 in complex with three L7/12 N-terminal-domain dimers, refine the structure of an archaeal L10E N-terminal domain on the 50S subunit, and identify these elements in cryo-electron-microscopic reconstructions of Escherichia coli ribosomes. The mobile C-terminal helix alpha8 of L10 carries three L7/12 dimers in T. maritima and two in E. coli, in concordance with the different length of helix alpha8 of L10 in these organisms. The stalk is organized into three elements (stalk base, L10 helix alpha8-L7/12 N-terminal-domain complex, and L7/12 C-terminal domains) linked by flexible connections. Highly mobile L7/12 C-terminal domains promote recruitment of translation factors to the ribosome and stimulate GTP hydrolysis by the ribosome bound factors through stabilization of their active GTPase conformation.
About this StructureAbout this Structure
1ZAX is a Protein complex structure of sequences from Thermotoga maritima. Full crystallographic information is available from OCA.
ReferenceReference
Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation., Diaconu M, Kothe U, Schlunzen F, Fischer N, Harms JM, Tonevitsky AG, Stark H, Rodnina MV, Wahl MC, Cell. 2005 Jul 1;121(7):991-1004. PMID:15989950
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Protein complex
- Thermotoga maritima
- Diaconu, M.
- Fischer, N.
- Harms, J M.
- Kothe, U.
- Rodnina, M V.
- Schluenzen, F.
- Stark, H.
- Tonevitski, A G.
- Wahl, M C.
- Cryo-electron microscopy
- Gtpase stimulation
- L10-l12 complex structure
- L10e structure
- L7/12 ribosomal stalk
- Mechanism of translation
- Rapid kinetic
- Ribosome structure and function
- Thiostrepton loop of 23s rrna
- Translation factor recruitment
- X-ray crystallography